Nectin3 - nectin cell adhesion molecule 3 Gene

Also Known as CD113; Pvrl3; 2610301B19Rik; 3000002N23Rik; 4921513D19Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 58998

Summary

Enables protein homodimerization activity. Involved in establishment of protein localization to plasma membrane and homophilic cell adhesion via plasma membrane adhesion molecules. Acts upstream of or within several processes, including camera-type eye morphogenesis; fertilization; and protein localization to cell junction. Located in several cellular components, including adherens junction; apical junction complex; and cell-cell contact zone. Is integral component of postsynaptic density membrane. Is active in hippocampal mossy fiber to CA3 synapse. Is expressed in several structures, including nervous system; sensory organ; skeletal musculature; tooth; and vibrissa. Orthologous to human NECTIN3 (nectin cell adhesion molecule 3). [provided by Alliance of Genome Resources, Apr 2022]

Nectin3 Products (3)

mRNA	Protein	Name
NM_021495.4	NP_067470.1	nectin-3 isoform alpha
NM_021496.3	NP_067471.1	nectin-3 isoform beta
NM_021497.2	NP_067472.1	nectin-3 isoform gamma

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12826663	MGI
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	12826663	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cell adhesion	IDA IDA: Inferred from direct assay	10744716	MGI
acts upstream of or within cell-cell adhesion	IDA IDA: Inferred from direct assay	12740392	MGI
involved in establishment of protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	23990464	MGI
acts upstream of or within fertilization	IMP IMP: Inferred from mutant phenotype	15728677	MGI
involved in homophilic cell adhesion via plasma membrane adhesion molecules	IDA IDA: Inferred from direct assay	12826663	MGI
acts upstream of or within lens morphogenesis in camera-type eye	IMP IMP: Inferred from mutant phenotype	15728677	MGI
acts upstream of or within protein localization to cell junction	IDA IDA: Inferred from direct assay	22512338	MGI
acts upstream of or within protein localization to cell junction	IMP IMP: Inferred from mutant phenotype	22512338	MGI
involved in regulation of postsynapse assembly	IDA IDA: Inferred from direct assay	28872640	MGI
involved in regulation of postsynapse assembly	IMP IMP: Inferred from mutant phenotype	28872640	MGI
acts upstream of or within retina morphogenesis in camera-type eye	IMP IMP: Inferred from mutant phenotype	15728677	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in adherens junction	IDA IDA: Inferred from direct assay	10744716	MGI
located in apical junction complex	IDA IDA: Inferred from direct assay	16249236	MGI
located in cell-cell contact zone	IDA IDA: Inferred from direct assay	23533177	MGI
located in cell-cell junction	IDA IDA: Inferred from direct assay	12759359	MGI
is active in hippocampal mossy fiber to CA3 synapse	IDA IDA: Inferred from direct assay	11827984	MGI
is active in hippocampal mossy fiber to CA3 synapse	IEP IEP: Inferred from expression pattern	11827984	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	12826663	MGI
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	11827984	MGI
is active in postsynaptic density membrane	IEP IEP: Inferred from expression pattern	11827984	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
nectin-3	poliovirus receptor-related 3 poliovirus receptor-related protein 3

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09176	NECTIN3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nectin3	NCBI	NCBI:25945