2. Gene
  3. Nectin3 - nectin cell adhesion molecule 3 Gene

Nectin3 - nectin cell adhesion molecule 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as CD113; Pvrl3; 2610301B19Rik; 3000002N23Rik; 4921513D19Rik

Gene ID: 58998 | Gene type: protein coding

About Nectin3

Summary

Enables protein homodimerization activity. Involved in establishment of protein localization to plasma membrane and homophilic cell adhesion via plasma membrane adhesion molecules. Acts upstream of or within several processes, including camera-type eye morphogenesis; fertilization; and protein localization to cell junction. Located in several cellular components, including adherens junction; apical junction complex; and cell-cell contact zone. Is integral component of postsynaptic density membrane. Is active in hippocampal mossy fiber to CA3 synapse. Is expressed in several structures, including nervous system; sensory organ; skeletal musculature; tooth; and vibrissa. Orthologous to human NECTIN3 (nectin cell adhesion molecule 3). [provided by Alliance of Genome Resources, Apr 2022]

Nectin3 Products(3)

mRNA Protein Name
NM_021495.4 NP_067470.1 nectin-3 isoform alpha
NM_021496.3 NP_067471.1 nectin-3 isoform beta
NM_021497.2 NP_067472.1 nectin-3 isoform gamma
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
12826663 MGI
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
12826663 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cell adhesion IDA
IDA: Inferred from direct assay
10744716 MGI
acts upstream of or within cell-cell adhesion IDA
IDA: Inferred from direct assay
12740392 MGI
involved in establishment of protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
23990464 MGI
acts upstream of or within fertilization IMP
IMP: Inferred from mutant phenotype
15728677 MGI
involved in homophilic cell adhesion via plasma membrane adhesion molecules IDA
IDA: Inferred from direct assay
12826663 MGI
acts upstream of or within lens morphogenesis in camera-type eye IMP
IMP: Inferred from mutant phenotype
15728677 MGI
acts upstream of or within protein localization to cell junction IDA
IDA: Inferred from direct assay
22512338 MGI
acts upstream of or within protein localization to cell junction IMP
IMP: Inferred from mutant phenotype
22512338 MGI
involved in regulation of postsynapse assembly IDA
IDA: Inferred from direct assay
28872640 MGI
involved in regulation of postsynapse assembly IMP
IMP: Inferred from mutant phenotype
28872640 MGI
acts upstream of or within retina morphogenesis in camera-type eye IMP
IMP: Inferred from mutant phenotype
15728677 MGI
Cellular Component GO Annotation Evidence Reference Source
located in adherens junction IDA
IDA: Inferred from direct assay
10744716 MGI
located in apical junction complex IDA
IDA: Inferred from direct assay
16249236 MGI
located in cell-cell contact zone IDA
IDA: Inferred from direct assay
23533177 MGI
located in cell-cell junction IDA
IDA: Inferred from direct assay
12759359 MGI
is active in hippocampal mossy fiber to CA3 synapse IDA
IDA: Inferred from direct assay
11827984 MGI
is active in hippocampal mossy fiber to CA3 synapse IEP
IEP: Inferred from expression pattern
11827984 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
12826663 MGI
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
11827984 MGI
is active in postsynaptic density membrane IEP
IEP: Inferred from expression pattern
11827984 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nectin-3

poliovirus receptor-related 3

poliovirus receptor-related protein 3

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09176 NECTIN3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nectin3 NCBI NCBI:25945