Gucy1a1 - guanylate cyclase 1, soluble, alpha 1 Gene

Also Known as Gucy1a3; sGC-alpha1; GCS-alpha-1; GCS-alpha-3; 1200016O07Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 60596

Summary

Predicted to enable Guanylate Cyclase activity and ion binding activity. Predicted to contribute to Adenylate Cyclase activity and cytidylate cyclase activity. Involved in retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission. Acts upstream of or within several processes, including cGMP biosynthetic process; positive regulation of nitric oxide mediated signal transduction; and relaxation of vascular associated smooth muscle. Located in GABA-ergic synapse and glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skeleton. Used to study primary open angle glaucoma. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human GUCY1A1 (Guanylate Cyclase 1 soluble subunit alpha 1). [provided by Alliance of Genome Resources, Apr 2022]

Gucy1a1 Products (3)

mRNA Protein Name
NM_001356987.1 NP_001343916.1 guanylate cyclase soluble subunit alpha-1
NM_001356988.1 NP_001343917.1 guanylate cyclase soluble subunit alpha-1
NM_021896.6 NP_068696.2 guanylate cyclase soluble subunit alpha-1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within cGMP biosynthetic process IMP
IMP: Inferred from mutant phenotype
16614755 MGI
acts upstream of nitric oxide mediated signal transduction IMP
IMP: Inferred from mutant phenotype
16614755 MGI
acts upstream of or within positive regulation of nitric oxide mediated signal transduction IMP
IMP: Inferred from mutant phenotype
16614755 MGI
acts upstream of or within regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
16614755 MGI
acts upstream of or within relaxation of vascular associated smooth muscle IMP
IMP: Inferred from mutant phenotype
16614755 MGI
involved in retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission IDA
IDA: Inferred from direct assay
28782641 MGI
involved in retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission IMP
IMP: Inferred from mutant phenotype
28782641 MGI
Cellular Component GO Annotation Evidence References Source
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
28782641 MGI
is active in GABA-ergic synapse IMP
IMP: Inferred from mutant phenotype
28782641 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
28782641 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
28782641 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

guanylate cyclase soluble subunit alpha-1

  • guanylate cyclase 1, soluble, alpha 3

  • guanylate cyclase soluble subunit alpha-3

  • soluble guanylate cyclase large subunit

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05918 GUCY1A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05920 GUCY1B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gucy1a1 NCBI NCBI:2982