Mapk8ip2 - mitogen-activated protein kinase 8 interacting protein 2 Gene

Also Known as IB2; Jip2; 3230402N03Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 60597

Summary

Enables Kinesin binding activity. Involved in several processes, including behavioral fear response; excitatory postsynaptic potential; and regulation of neurotransmitter receptor activity. Acts upstream of or within JNK cascade. Located in cytoplasm; neuronal cell body; and postsynaptic density. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and skeleton. Orthologous to human MAPK8IP2 (mitogen-activated protein kinase 8 interacting protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Mapk8ip2 Products (1)

mRNA	Protein	Name
NM_021921.3	NP_068740.3	C-Jun-amino-terminal kinase-interacting protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables kinesin binding	IPI IPI: Inferred from physical interaction	11238452	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10827173	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within JNK cascade	IDA IDA: Inferred from direct assay	10827199	MGI
involved in behavioral fear response	IMP IMP: Inferred from mutant phenotype	21048139	MGI
involved in dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	21048139	MGI
involved in excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	21048139	MGI
involved in mating behavior	IMP IMP: Inferred from mutant phenotype	21048139	MGI
involved in nonassociative learning	IMP IMP: Inferred from mutant phenotype	21048139	MGI
involved in regulation of AMPA receptor activity	IMP IMP: Inferred from mutant phenotype	21048139	MGI
involved in regulation of NMDA receptor activity	IMP IMP: Inferred from mutant phenotype	21048139	MGI
involved in regulation of signaling receptor activity	IMP IMP: Inferred from mutant phenotype	21048139	MGI
involved in regulation of synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	21048139	MGI
involved in social behavior	IMP IMP: Inferred from mutant phenotype	21048139	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16018997	MGI
located in neuronal cell body	IDA IDA: Inferred from direct assay	16301330	MGI
located in postsynaptic density	IDA IDA: Inferred from direct assay	21048139	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
C-Jun-amino-terminal kinase-interacting protein 2	IB-2 JIP-2 JNK MAP kinase scaffold protein 2 JNK-interacting protein 2 islet-brain-2

Mapk8ip2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Mapk8ip2	Q9ERE9	Lrp2	Mus musculus	A2ARV4	Y2H	10827173
Intra	Mapk8ip2	Q9ERE9	Lrp2	Mus musculus	A2ARV4	Pull Down	10827173
Intra	Mapk8ip2	Q9ERE9	Lrp1	Mus musculus	Q91ZX7	Pull Down	10827173
Intra	Mapk8ip2	Q9ERE9	Lrp1	Mus musculus	Q91ZX7	Y2H	10827173
Cross	Mapk8ip2	Q9ERE9	Appl	Drosophila melanogaster	P14599	Anti Tag CoIP	11912189
Cross	Mapk8ip2	Q9ERE9	Appl	Drosophila melanogaster	P14599	Pull Down	11912189

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08125	MAPK8IP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mapk8ip2	NCBI	NCBI:23542