MAPK8IP2 - mitogen-activated protein kinase 8 interacting protein 2 Gene

Also Known as IB2; IB-2; JIP2; PRKM8IPL

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23542

About MAPK8IP2

Cytogenetic location: 22q13.33 Genomic coordinates (GRCh38): 22:50,600,793-50,613,978 (from NCBI)

This gene has 2 transcripts (splice variants), 211 orthologues and 11 paralogues. Biased expression in brain (RPKM 21.8), adrenal (RPKM 2.8) and 2 other tissues.

Summary

This gene encodes a scaffold protein that is thought to be involved in the regulation of the c-Jun amino-terminal kinase signaling pathway. This protein has been shown to interact with and regulate the activity of MAPK8/JNK1 and MAP2K7/MKK7 kinases. [provided by RefSeq, Jun 2017]

MAPK8IP2 Products (1)

mRNA	Protein	Name
NM_012324.6	NP_036456.1	C-Jun-amino-terminal kinase-interacting protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables MAP-kinase scaffold activity	IDA IDA: Inferred from direct assay	10756100	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16273093	GOA
enables protein kinase activator activity	IDA IDA: Inferred from direct assay	12244047	GOA
enables protein kinase activator activity	IGI IGI: Inferred from genetic interaction	12244047	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	10490659	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within MAPK cascade	IDA IDA: Inferred from direct assay	12244047	GOA
involved in negative regulation of apoptotic signaling pathway	IDA IDA: Inferred from direct assay	10756100	GOA
involved in regulation of JNK cascade	IDA IDA: Inferred from direct assay	10490659	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10490659	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAPK8IP2 Protein Structure

SH3_9

PID

0
200
400
600
823 a.a.

Protein Preferred Names	Protein Names
C-Jun-amino-terminal kinase-interacting protein 2	JNK MAP kinase scaffold protein 2

MAPK8IP2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MAPK8IP2	Q13387	ERBB2	Homo sapiens	P04626	Protein Array	16273093
Intra	MAPK8IP2	Q13387	UBD	Homo sapiens	O15205	Y2H Array	25814554
Intra	MAPK8IP2	Q13387	UBD	Homo sapiens	O15205	Lumier	25814554
Intra	MAPK8IP2	Q13387	q53hf2_human	Homo sapiens	Q53HF2	Y2H Array	25814554

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Spinocerebellar Ataxia, X-Linked 5	SCAX5 X-Linked Spinocerebellar Ataxia 5 X-Linked Non Progressive Cerebellar Ataxia
Polyomavirus-Associated Nephropathy	Polyomavirus Associated Nephropathy Pvan
Hemorrhagic Cystitis
Phelan-Mcdermid Syndrome	Chromosome 22q13.3 Deletion Syndrome 22q13.3 Deletion Syndrome Telomeric 22q13 Monosomy Syndrome PHMDS Deletion 22q13 Syndrome 22q13.3 Deletion Deletion 22q13.3 Syndrome Monosomy 22q13 Monosomy 22q13.3 22q13 Deletion Syndrome Monosomy 22q13 Syndrome 22q13 Deletion Chromosome Deletion
X-Linked Cerebellar Ataxia
Theileriasis	Theileriosis Infection By Theileria

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08125	MAPK8IP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MAPK8IP2	RGD	RGD:1309727
Felis catus	MAPK8IP2	VGNC	VGNC:109516
Mus musculus	MAPK8IP2	MGD	MGI:1926555
Canis familiaris	MAPK8IP2	VGNC	VGNC:43002
Bos taurus	MAPK8IP2	VGNC	VGNC:31225
Others	MAPK8IP2	NCBI