2. Gene
  3. MAPK8IP2 - mitogen-activated protein kinase 8 interacting protein 2 Gene

MAPK8IP2 - mitogen-activated protein kinase 8 interacting protein 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as IB2; IB-2; JIP2; PRKM8IPL

Gene ID: 23542 | Gene type: protein coding

About MAPK8IP2

Cytogenetic location: 22q13.33 Genomic coordinates (GRCh38): 22:50,600,793-50,613,978 (from NCBI)

This gene has 2 transcripts (splice variants), 211 orthologues and 11 paralogues. Biased expression in brain (RPKM 21.8), adrenal (RPKM 2.8) and 2 other tissues.

Summary

This gene encodes a scaffold protein that is thought to be involved in the regulation of the c-Jun amino-terminal kinase signaling pathway. This protein has been shown to interact with and regulate the activity of MAPK8/JNK1 and MAP2K7/MKK7 kinases. [provided by RefSeq, Jun 2017]

MAPK8IP2 Products(1)

mRNA Protein Name
NM_012324.6 NP_036456.1 C-Jun-amino-terminal kinase-interacting protein 2

MAPK8IP2 Protein Structure

SH3_9

SH3_9: Variant SH3 domain (610 - 659)

PID

PID: Phosphotyrosine interaction domain (PTB/PID) (682 - 812)

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  • 823 a.a.
Protein Preferred Names Protein Names

C-Jun-amino-terminal kinase-interacting protein 2

JNK MAP kinase scaffold protein 2

Related Diseases

Diseases Alias
Spinocerebellar Ataxia, X-Linked 5

SCAX5

X-Linked Spinocerebellar Ataxia 5

X-Linked Non Progressive Cerebellar Ataxia
Polyomavirus-Associated Nephropathy

Polyomavirus Associated Nephropathy

Pvan
Hemorrhagic Cystitis
Phelan-Mcdermid Syndrome

Chromosome 22q13.3 Deletion Syndrome

22q13.3 Deletion Syndrome

Telomeric 22q13 Monosomy Syndrome

PHMDS

Deletion 22q13 Syndrome

22q13.3 Deletion

Deletion 22q13.3 Syndrome

Monosomy 22q13

Monosomy 22q13.3

22q13 Deletion Syndrome

Monosomy 22q13 Syndrome

22q13 Deletion

Chromosome Deletion
X-Linked Cerebellar Ataxia
Theileriasis

Theileriosis

Infection By Theileria
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08125 MAPK8IP2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MAPK8IP2 RGD RGD:1309727
Felis catus MAPK8IP2 VGNC VGNC:109516
Mus musculus MAPK8IP2 MGD MGI:1926555
Canis familiaris MAPK8IP2 VGNC VGNC:43002
Bos taurus MAPK8IP2 VGNC VGNC:31225