UBD - ubiquitin D Gene

Also Known as FAT10; UBD-3; GABBR1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10537

About UBD

Cytogenetic location: 6p22.1 Genomic coordinates (GRCh38): 6:29,555,515-29,559,732 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 104 orthologues and 10 paralogues. Biased expression in lymph node (RPKM 113.8), appendix (RPKM 64.9) and 10 other tissues.

Summary

This gene encodes a protein which contains two ubiquitin-like domains and appears to have similar function to ubiquitin. Through covalent attachment, the encoded protein targets Other proteins for 26S Proteasome degradation. This protein has been implicated to function in many cellular processes, including caspase-dependent Apoptosis, formation of aggresomes, mitotic regulation, and dendritic cell maturation. Upregulation of this gene may promote inflammation in chronic kidney disease and has been observed in many Cancer types. [provided by RefSeq, Aug 2017]

UBD Products (1)

mRNA Protein Name
NM_006398.4 NP_006389.2 ubiquitin D

UBD Protein Structure

ubiquitin

ubiquitin: Ubiquitin family (20 - 79)

ubiquitin

ubiquitin: Ubiquitin family (101 - 159)

  • 0
  • 100
  • 165 a.a.
Protein Preferred Names Protein Names

ubiquitin D

  • diubiquitin

UBD Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
UBD O15205 PDE9A Homo sapiens O76083-2
Y2H Prey Pooling
32296183
Intra
UBD O15205 PDE9A Homo sapiens O76083-2
Validated Y2H
32296183
Intra
UBD O15205 PDE9A Homo sapiens O76083-2
Y2H Array
32296183
Intra
UBD O15205 NUB1 Homo sapiens Q9Y5A7
Anti Tag CoIP
33961781
Intra
UBD O15205 UBE2Z Homo sapiens Q9H832
Anti Tag CoIP
24528925
Intra
UBD O15205 UBE2Z Homo sapiens Q9H832
Anti Bait CoIP
24528925
Intra
UBD O15205 MAPK8IP2 Homo sapiens Q13387
Validated Y2H
25814554
Intra
UBD O15205 SNCA Homo sapiens P37840
Validated Y2H
32814053
Intra
UBD O15205 SNCA Homo sapiens P37840
Y2H Array
32814053
Intra
UBD O15205 SNCA Homo sapiens P37840
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

UBD Antibodies

Cat. No. Product Name Application Reactivity
HY-P80364 Ubiquitin D Antibody (YA021) WB, ICC/IF, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Kidney Disease

  • Renal Failure

  • Kidney Failure

  • Kidney Diseases

  • Nephropathy

  • Abnormality Of The Kidney

  • Impaired Renal Function Disease

  • Renal Anomaly

  • Kidney Dysfunction

  • Renal Disease

  • Nephropathies

  • Renal Failure Adverse Event

  • Abnormal Renal Function
Chronic Kidney Disease

  • Chronic Renal Disease

  • Chronic Kidney Failure

  • Ckd

  • Chronic Renal Failure

  • Kidney Failure, Chronic

  • Chronic Renal Failure Syndrome

  • Crf

  • Renal Failure - Chronic

  • Renal Failure Chronic

  • Chronic Kidney Diseases

  • Chronic Kidney Disease Stage 5

  • Ckd - [Chronic Kidney Disease]

  • Crf - [Chronic Renal Failure]

  • Chronic Kidney Impairment

  • Chronic Renal Impairment

  • Chronic Kidney Shutdown

  • Chronic Hypoxic Kidney Failure

  • Chronic Kidney Collapse

  • Chronic Renal Insufficiency

  • Chronic Kidney Toxaemia

  • Chronic Kidney Hypofunction

  • Chronic Renal Suppression

  • Chronic Renal Failure, Stage 5

  • Ckd - [Chronic Kidney Disease] Stage 5

  • End Stage Kidney Failure

  • End Stage Renal Failure

  • End Stage Kidney Disease

  • End Stage Renal Disease

  • End Stage Chronic Renal Failure

  • Esrf - [End Stage Renal Failure]

  • Esrd - [End Stage Renal Diseases]

  • Egfr - [Estimated Glomerular Filtration Rate] < 15 Ml/Min/1.73m²
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Polycystic Kidney Disease

  • Polycystic Kidney Diseases

  • Pkd

  • Polycystic Renal Disease

  • Kidney Disease, Polycystic

  • Polycystic Kidney, Autosomal Dominant
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-139979 USP5-IN-1 Inhibitor 99.73% Unkown
HY-155697 SGC-UBD253 Antagonist 99.3% Unkown
HY-RS15335 UBD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-157428 USP3 ZnF-UBD ligand-1 99.61% Unkown
HY-172193 UBD1031 Antagonist / Unkown
HY-180994 HDAC6-IN-72 Inhibitor / Unkown
HY-W027296 UBTR008295a Ligand / Unkown
HY-RS17264 Ubd Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23718 Ubd Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta UBD VGNC VGNC:104439
Rattus norvegicus UBD RGD RGD:69418
Mus musculus UBD MGD MGI:1344410
Others UBD NCBI