S100A3 - S100 calcium binding protein A3 Gene

Also Known as S100E

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6274

About S100A3

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:153,547,329-153,549,258 (from NCBI)

This gene has 2 transcripts (splice variants), 337 orthologues and 21 paralogues. Biased expression in lung (RPKM 11.5), skin (RPKM 3.7) and 10 other tissues.

Summary

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has the highest content of cysteines of all S100 proteins, has a high affinity for Zinc, and is highly expressed in human hair cuticle. The precise function of this protein is unknown. [provided by RefSeq, Jul 2008]

S100A3 Products (1)

mRNA Protein Name
NM_002960.2 NP_002951.1 protein S100-A3

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
31837246 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

S100A3 Protein Structure

S_100

S_100: S-100/ICaBP type calcium binding domain (5 - 46)

  • 0
  • 101 a.a.
Protein Preferred Names Protein Names

protein S100-A3

S100A3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
S100A3 P33764 TRPM4 Homo sapiens Q8TD43
FPS
31837246
Intra
S100A3 P33764 S100Z Homo sapiens Q8WXG8
Validated Y2H
32296183
Intra
S100A3 P33764 S100Z Homo sapiens Q8WXG8
Y2H Prey Pooling
32296183
Intra
S100A3 P33764 S100Z Homo sapiens Q8WXG8
Y2H Array
32296183
Intra
S100A3 P33764 TP53 Homo sapiens P04637
FPS
31837246
Intra
S100A3 P33764 S100A10 Homo sapiens P60903
Y2H Array
32296183
Intra
S100A3 P33764 S100A10 Homo sapiens P60903
Y2H Prey Pooling
32296183
Intra
S100A3 P33764 S100A10 Homo sapiens P60903
Validated Y2H
32296183
Intra
S100A3 P33764 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
Intra
S100A3 P33764 S100A2 Homo sapiens P29034
Y2H Prey Pooling
32296183
Intra
S100A3 P33764 S100A2 Homo sapiens P29034
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant S100A3 Proteins

Cat. No. Product Name Accession Purity
HY-P76585 S100A3 Protein, Human (His-MBP) P33764 (M1-Q101) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Pilomatrixoma

  • Pilomatricoma

  • PTR

  • Epithelioma Calcificans Of Malherbe

  • Benign Pilomatricoma

  • Calcifying Epithelioma Of Malherbe

  • Pilomatricoma, Somatic

  • Benign Pilomatrixoma

  • Malherbe Calcifying Epithelioma
Classic Pulmonary Blastoma

  • Biphasic Pulmonary Blastoma
Epidermoid Cysts

  • Epidermoid Cyst

  • Sebaceous Cyst

  • Epidermal Inclusion Cyst

  • Epidermal Cyst
Anaplastic Astrocytoma

  • Grade Iii Astrocytoma

  • Astrocytoma, Anaplastic

  • Grade Iii Astrocytic Tumor
Psoriasis 7

  • PSORS7

  • Psoriasis 7, Susceptibility To

  • Psoriasis Susceptibility 7

  • Psoriasis

  • Psoriasis Vulgaris

  • Pv
Hypotrichosis 2

  • HYPT2

  • Hypotrichosis Simplex Of The Scalp 1

  • Htss1

  • Htss

  • Hypotrichosis, Spanish Type

  • Spanish Type Hypotrichosis

  • Hypotrichosis Spanish Type

  • Hypotrichosis, Type 2

  • Hypotrichosis Simplex Of Scalp
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12379 S100A3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18567 S100a3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25051 S100a3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus S100A3 RGD RGD:620260
Macaca mulatta S100A3 VGNC VGNC:76957
Mus musculus S100A3 MGD MGI:1338849
Bos taurus S100A3 VGNC VGNC:34243
Canis familiaris S100A3 VGNC VGNC:45829
Others S100A3 NCBI