NFKBIZ - NFKB inhibitor zeta Gene

Also Known as IKBZ; INAP; MAIL

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64332

About NFKBIZ

Cytogenetic location: 3q12.3 Genomic coordinates (GRCh38): 3:101,827,990-101,861,022 (from NCBI)

This gene has 11 transcripts (splice variants), 190 orthologues and 3 paralogues. Broad expression in bone marrow (RPKM 120.3), urinary bladder (RPKM 31.0) and 18 other tissues.

Summary

This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

NFKBIZ Products (2)

mRNA Protein Name
NM_001005474.3 NP_001005474.1 NF-kappa-B inhibitor zeta isoform b
NM_031419.4 NP_113607.1 NF-kappa-B inhibitor zeta isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25107474 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
23071313 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NFKBIZ Protein Structure

Ank_2

Ank_2: Ankyrin repeats (3 copies) (448 - 531)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (593 - 683)

  • 0
  • 200
  • 400
  • 600
  • 718 a.a.
Protein Preferred Names Protein Names

NF-kappa-B inhibitor zeta

  • I-kappa-B-zeta

NFKBIZ Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
NFKBIZ Q9BYH8 Akirin2 Mus musculus B1AXD8
Anti Bait CoIP
25107474
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Psoriasis 6

  • PSORS6

  • Psoriasis Susceptibility 6

  • Psoriasis 6, Susceptibility To
Premature Ovarian Failure 18

  • POF18

  • Primary Ovarian Insufficiency 18

  • Ovarian Failure, Premature, Type 18
Early Infantile Epileptic Encephalopathy

  • Early Infantile Epileptic Encephalopathy With Burst-Suppression

  • Early Infantile Epileptic Encephalopathy With Suppression Bursts

  • Eiee

  • Early Infantile Epileptic Encephalopathy With Suppression-Bursts

  • Ohtahara Syndrome

  • Encephalopathy, Epileptic, Early Infantile
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09265 NFKBIZ Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NFKBIZ VGNC VGNC:32050
Rattus norvegicus NFKBIZ RGD RGD:1310834
Mus musculus NFKBIZ MGD MGI:1931595
Canis familiaris NFKBIZ VGNC VGNC:43785
Felis catus NFKBIZ VGNC VGNC:63791
Macaca mulatta NFKBIZ VGNC VGNC:75276
Others NFKBIZ NCBI