2. Gene
  3. NFKBIZ - NFKB inhibitor zeta Gene

NFKBIZ - NFKB inhibitor zeta Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as IKBZ; INAP; MAIL

Gene ID: 64332 | Gene type: protein coding

About NFKBIZ

Cytogenetic location: 3q12.3 Genomic coordinates (GRCh38): 3:101,827,990-101,861,022 (from NCBI)

This gene has 11 transcripts (splice variants), 190 orthologues and 3 paralogues. Broad expression in bone marrow (RPKM 120.3), urinary bladder (RPKM 31.0) and 18 other tissues.

Summary

This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

NFKBIZ Products(2)

mRNA Protein Name
NM_001005474.3 NP_001005474.1 NF-kappa-B inhibitor zeta isoform b
NM_031419.4 NP_113607.1 NF-kappa-B inhibitor zeta isoform a

NFKBIZ Protein Structure

Ank_2

Ank_2: Ankyrin repeats (3 copies) (448 - 531)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (593 - 683)

  • 0
  • 200
  • 400
  • 600
  • 718 a.a.
Protein Preferred Names Protein Names

NF-kappa-B inhibitor zeta

I-kappa-B-zeta

Related Diseases

Diseases Alias
Psoriasis 6

PSORS6

Psoriasis Susceptibility 6

Psoriasis 6, Susceptibility To
Premature Ovarian Failure 18

POF18

Primary Ovarian Insufficiency 18

Ovarian Failure, Premature, Type 18
Early Infantile Epileptic Encephalopathy

Early Infantile Epileptic Encephalopathy With Burst-Suppression

Early Infantile Epileptic Encephalopathy With Suppression Bursts

Eiee

Early Infantile Epileptic Encephalopathy With Suppression-Bursts

Ohtahara Syndrome

Encephalopathy, Epileptic, Early Infantile
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09265 NFKBIZ Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NFKBIZ VGNC VGNC:32050
Rattus norvegicus NFKBIZ RGD RGD:1310834
Mus musculus NFKBIZ MGD MGI:1931595
Canis familiaris NFKBIZ VGNC VGNC:43785
Felis catus NFKBIZ VGNC VGNC:63791
Macaca mulatta NFKBIZ VGNC VGNC:75276