Akirin2 - akirin 2 Gene

Also Known as Akirin-2; 2700059D21Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 433693

Summary

Predicted to enable enzyme binding activity; identical protein binding activity; and transcription coregulator activity. Involved in embryo development. Acts upstream of or within positive regulation of interleukin-6 production; positive regulation of transcription by RNA polymerase II; and response to lipopolysaccharide. Predicted to be located in nucleoplasm. Predicted to be part of transcription repressor complex. Predicted to be active in chromatin and nucleus. Orthologous to human AKIRIN2 (akirin 2). [provided by Alliance of Genome Resources, Apr 2022]

Akirin2 Products (1)

mRNA	Protein	Name
NM_001007589.3	NP_001007590.2	akirin-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25107474	MGI
enables protein-macromolecule adaptor activity	IDA IDA: Inferred from direct assay	25107474	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in cerebral cortex development	IMP IMP: Inferred from mutant phenotype	27871306	MGI
involved in defense response to bacterium	IMP IMP: Inferred from mutant phenotype	25107474	MGI
involved in embryo development ending in birth or egg hatching	IMP IMP: Inferred from mutant phenotype	18066067	MGI
involved in positive regulation of B cell activation	IMP IMP: Inferred from mutant phenotype	26041538	MGI
involved in positive regulation of adaptive immune response	IMP IMP: Inferred from mutant phenotype	26041538	MGI
involved in positive regulation of innate immune response	IMP IMP: Inferred from mutant phenotype	25107474	MGI
involved in positive regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	25107474	MGI
acts upstream of or within positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	18066067	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	25107474	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18066067	MGI
involved in regulation of muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	30801883	MGI
acts upstream of or within response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	18066067	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	30801883	MGI
located in membrane	IDA IDA: Inferred from direct assay	30801883	MGI
is active in nucleus	IDA IDA: Inferred from direct assay	25107474	MGI
located in nucleus	IDA IDA: Inferred from direct assay	30801883	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
akirin-2

Akirin2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Akirin2	B1AXD8	Nfkbiz	Mus musculus	Q9EST8	Anti Tag CoIP	25107474
Intra	Akirin2	B1AXD8	Smarcd1	Mus musculus	Q61466	Anti Bait CoIP	25107474
Intra	Akirin2	B1AXD8	Smarcd1	Mus musculus	Q61466	Anti Tag CoIP	25107474
Cross	Akirin2	B1AXD8	NFKBIZ	Homo sapiens	Q9BYH8	Anti Tag CoIP	25107474

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00528	AKIRIN2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Akirin2	NCBI	NCBI:55122