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CSMD1 - CUB and Sushi multiple domains 1 Gene

Also Known as PPP1R24

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 64478

About CSMD1

Cytogenetic location: 8p23.2 Genomic coordinates (GRCh38): 8:2,935,361-4,994,914 (from NCBI)

This gene has 17 transcripts (splice variants), 211 orthologues and 39 paralogues. Biased expression in brain (RPKM 2.2), testis (RPKM 1.7) and 5 other tissues.

Summary

Predicted to act upstream of or within several processes, including learning or memory; mammary gland branching involved in pregnancy; and reproductive structure development. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

CSMD1 Products (1)

mRNA	Protein	Name
NM_033225.6	NP_150094.5	CUB and sushi domain-containing protein 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22538441	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CSMD1 Protein Structure

CUB

Sushi

CUB

Sushi

CUB

Sushi

CUB

Sushi

CUB

Sushi

CUB

Sushi

CUB

Sushi

CUB

Sushi

CUB

Sushi

CUB

Sushi

CUB

Sushi

CUB

Sushi

CUB

Sushi

CUB

Sushi

0
600
1200
1800
2400
3000
3564 a.a.

Protein Preferred Names	Protein Names
CUB and sushi domain-containing protein 1	protein phosphatase 1, regulatory subunit 24

CSMD1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CSMD1	Q96PZ7	SMAD3	Homo sapiens	P84022	Anti Bait CoIP	22538441
Intra	CSMD1	Q96PZ7	SMAD3	Homo sapiens	P84022	Anti Tag CoIP	22538441
Intra	CSMD1	Q96PZ7	SMAD3	Homo sapiens	P84022	IF	22538441

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Aceruloplasminemia	Cerebellar Ataxia Hypoceruloplasminemia Hemosiderosis, Systemic, Due To Aceruloplasminemia Familial Apoceruloplasmin Deficiency Hereditary Ceruloplasmin Deficiency Deficiency Of Ferroxidase Hypoceruloplasminemia, Hereditary Ceruloplasmin Deficiency Systemic Hemosiderosis Due To Aceruloplasminemia ACERULOP
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Vallecula Cancer	Malignant Tumor Of Vallecula
Cannabis Dependence	Marijuana Abuse Cannabinoid Addiction Cannabinoid Dependence Cannabis Addiction
Hallucinogen Dependence	Hallucinogen Addiction
Autosomal Dominant Intellectual Developmental Disorder 8	Autosomal Dominant Non-Syndromic Intellectual Disability 8 Mental Retardation, Autosomal Dominant 8 Autosomal Dominant Mental Retardation 8 Mrd8
Smallpox	Variola Ordinary Smallpox Alastrim Amaas
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2
Familial Adult Myoclonic Epilepsy	Benign Adult Familial Myoclonus Epilepsy Bafme Benign Adult Familial Myoclonic Epilepsy Fame Familial Cortical Myoclonic Tremor And Epilepsy Fcmte Adcme Autosomal Dominant Cortical Myoclonus And Epilepsy Fam Epilepsy, Myoclonic, Familial Adult Epilepsy, Myoclonic, Benign Adult Familial, Type 2
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03239	CSMD1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CSMD1	MGD	MGI:2137383
Bos taurus	CSMD1	VGNC	VGNC:59330
Canis familiaris	CSMD1	VGNC	VGNC:39662
Felis catus	CSMD1	VGNC	VGNC:61222
Rattus norvegicus	CSMD1	RGD	RGD:1305103
Macaca mulatta	CSMD1	VGNC	VGNC:71402
Others	CSMD1	NCBI