Fntb - farnesyltransferase, CAAX box, beta Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 64511

Summary

Contributes to peptide binding activity and protein farnesyltransferase activity. Involved in several processes, including positive regulation of cell cycle; positive regulation of cell population proliferation; and positive regulation of nitric-oxide synthase biosynthetic process. Predicted to be part of microtubule associated complex and protein farnesyltransferase complex. Orthologous to several human genes including CHURC1-FNTB (CHURC1-FNTB readthrough). [provided by Alliance of Genome Resources, Apr 2022]

Fntb Products (1)

mRNA Protein Name
NM_172034.2 NP_742031.1 protein farnesyltransferase subunit beta

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
contributes to peptide binding IDA
IDA: Inferred from direct assay
9705207 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9065406 RGD
contributes to protein farnesyltransferase activity IDA
IDA: Inferred from direct assay
8089111 RGD
enables protein farnesyltransferase activity IDA
IDA: Inferred from direct assay
1855253 RGD
Biological Process GO Annotation Evidence References Source
involved in positive regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
10544242 RGD
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
10544242 RGD
involved in positive regulation of nitric-oxide synthase biosynthetic process IMP
IMP: Inferred from mutant phenotype
9153192 RGD
involved in response to cytokine IMP
IMP: Inferred from mutant phenotype
9153192 RGD
involved in response to organic cyclic compound IMP
IMP: Inferred from mutant phenotype
16257390 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein farnesyltransferase subunit beta

  • CAAX farnesyltransferase subunit beta

  • FTase-beta

  • farnesyltransferase beta subunit

  • ras proteins prenyltransferase subunit beta

Fntb Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Fntb Q02293 Fnta Rattus norvegicus Q04631
X-Ray Diffraction
12657282
Intra
Fntb Q02293 Fnta Rattus norvegicus Q04631
X-Ray Diffraction
15170324
Intra
Fntb Q02293 Fnta Rattus norvegicus Q04631
X-Ray Diffraction
12667062
Intra
Fntb Q02293 Fnta Rattus norvegicus Q04631
X-Ray Diffraction
12699757
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05026 FNTB Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fntb NCBI NCBI:2342