Fntb - farnesyltransferase, CAAX box, beta Gene

Rattus norvegicus

Gene ID: 64511 | Gene type: protein coding

About Fntb

Summary

Contributes to peptide binding activity and protein farnesyltransferase activity. Involved in several processes, including positive regulation of cell cycle; positive regulation of cell population proliferation; and positive regulation of nitric-oxide synthase biosynthetic process. Predicted to be part of microtubule associated complex and protein farnesyltransferase complex. Orthologous to several human genes including CHURC1-FNTB (CHURC1-FNTB readthrough). [provided by Alliance of Genome Resources, Apr 2022]

Fntb Products(1)

mRNA	Protein	Name
NM_172034.2	NP_742031.1	protein farnesyltransferase subunit beta

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to peptide binding	IDA IDA: Inferred from direct assay	9705207	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9065406	RGD
contributes to protein farnesyltransferase activity	IDA IDA: Inferred from direct assay	8089111	RGD
enables protein farnesyltransferase activity	IDA IDA: Inferred from direct assay	1855253	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	10544242	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	10544242	RGD
involved in positive regulation of nitric-oxide synthase biosynthetic process	IMP IMP: Inferred from mutant phenotype	9153192	RGD
involved in response to cytokine	IMP IMP: Inferred from mutant phenotype	9153192	RGD
involved in response to organic cyclic compound	IMP IMP: Inferred from mutant phenotype	16257390	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein farnesyltransferase subunit beta

CAAX farnesyltransferase subunit beta	FTase-beta
farnesyltransferase beta subunit	ras proteins prenyltransferase subunit beta

Fntb Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Fntb	Q02293	Fnta	Rattus norvegicus	Q04631	X-Ray Diffraction	12657282
Intra	Fntb	Q02293	Fnta	Rattus norvegicus	Q04631	X-Ray Diffraction	15170324
Intra	Fntb	Q02293	Fnta	Rattus norvegicus	Q04631	X-Ray Diffraction	12667062
Intra	Fntb	Q02293	Fnta	Rattus norvegicus	Q04631	X-Ray Diffraction	12699757

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05026	FNTB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fntb	NCBI	NCBI:2342

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