FNTB - farnesyltransferase, CAAX box, beta Gene

Also Known as FPTB

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2342

About FNTB

Cytogenetic location: 14q23.3 Genomic coordinates (GRCh38): 14:64,986,895-65,062,650 (from NCBI)

This gene has 8 transcripts (splice variants), 208 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 9.3), brain (RPKM 8.2) and 25 other tissues.

Summary

Enables zinc ion binding activity. Contributes to protein farnesyltransferase activity. Involved in protein farnesylation. Part of microtubule associated complex and protein farnesyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]

FNTB Products (1)

mRNA Protein Name
NM_002028.4 NP_002019.1 protein farnesyltransferase subunit beta

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11687658 GOA
contributes to protein farnesyltransferase activity IDA
IDA: Inferred from direct assay
19228685 GOA
enables protein farnesyltransferase activity IDA
IDA: Inferred from direct assay
16893176 GOA
enables zinc ion binding IDA
IDA: Inferred from direct assay
16893176 GOA
Biological Process GO Annotation Evidence References Source
involved in protein farnesylation IDA
IDA: Inferred from direct assay
16893176 GOA
Cellular Component GO Annotation Evidence References Source
part of microtubule associated complex IDA
IDA: Inferred from direct assay
19228685 GOA
part of protein farnesyltransferase complex IDA
IDA: Inferred from direct assay
16893176 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FNTB Protein Structure

SQHop_cyclase_N

SQHop_cyclase_N: Squalene-hopene cyclase N-terminal domain (129 - 240)

Prenyltrans

Prenyltrans: Prenyltransferase and squalene oxidase repeat (269 - 311)

Prenyltrans

Prenyltrans: Prenyltransferase and squalene oxidase repeat (331 - 373)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 437 a.a.
Protein Preferred Names Protein Names

protein farnesyltransferase subunit beta

  • CAAX farnesyltransferase subunit beta

Related Diseases

Diseases Alias
Myasthenic Syndrome, Congenital, 12

  • Congenital Myasthenic Syndrome 12

  • CMS12

  • Myasthenic Syndrome, Congenital, With Tubular Aggregates 1

  • Cmsta1

  • Myasthenia, Congenital, 12, With Tubular Aggregates

  • Congenital Myasthenia 12 With Tubular Aggregates

  • Limb-Girdle Myasthenia With Tubular Aggregates

  • Myasthenia, Congenital, With Tubular Aggregates 1

  • Myasthenic Syndrome, Congenital, With Tubular Aggregates, 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05026 FNTB Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus FNTB RGD RGD:620119
Mus musculus FNTB MGD MGI:1861305
Others FNTB NCBI