SPRR1A - small proline rich protein 1A Gene

Also Known as SPRK

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6698

About SPRR1A

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:152,984,081-152,985,814 (from NCBI)

This gene has 2 transcripts (splice variants), 62 orthologues and 20 paralogues. Restricted expression toward esophagus (RPKM 829.4).

Summary

A structural constituent of skin epidermis. Involved in keratinocyte differentiation and peptide cross-linking. Located in cornified envelope. [provided by Alliance of Genome Resources, Apr 2022]

SPRR1A Products (2)

mRNA Protein Name
NM_001199828.2 NP_001186757.1 cornifin-A
NM_005987.4 NP_005978.2 cornifin-A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10066784 GOA
enables structural constituent of skin epidermis IDA
IDA: Inferred from direct assay
7543090 GOA
Biological Process GO Annotation Evidence References Source
involved in keratinocyte differentiation IDA
IDA: Inferred from direct assay
10908733 GOA
involved in peptide cross-linking IDA
IDA: Inferred from direct assay
7543090 GOA
Cellular Component GO Annotation Evidence References Source
located in cornified envelope IDA
IDA: Inferred from direct assay
7543090 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPRR1A Protein Structure

Cornifin

Cornifin: Cornifin (SPRR) family (17 - 57)

Cornifin

Cornifin: Cornifin (SPRR) family (42 - 87)

  • 0
  • 89 a.a.
Protein Preferred Names Protein Names

cornifin-A

  • 19 kDa pancornulin

SPRR1A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SPRR1A P35321 GLIS1 Homo sapiens Q8NBF1
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Progesterone-Receptor Positive Breast Cancer
Macular Degeneration, Age-Related, 13

  • Age Related Macular Degeneration 13

  • ARMD13

  • Macular Degeneration, Age-Related, 13, Susceptibility To

  • Macular Degeneration, Age-Related, Type 13
Autosomal Recessive Congenital Ichthyosis

  • Lamellar Ichthyosis

  • Congenital Ichthyosiform Erythroderma

  • Li

  • Congenital Nonbullous Ichthyosiform Erythroderma

  • Arci

  • Congenital Lamellar Ichthyosis

  • Nonbullous Congenital Ichthyosiform Erythroderma

  • Cie

  • Congenital Non-Bullous Ichthyosiform Erythroderma

  • Erythrodermic Ichthyosis

  • Nbcie

  • Ncie

  • Non-Bullous Congenital Ichthyosiform Erythroderma

  • Collodion Baby

  • Ichthyosis, Lamellar

  • Non Bullous Congenital Ichthyosiform Erythroderma

  • Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form

  • Ichthyosiform Erythroderma, Congenital, Nonbullous, 1

  • Collodion Baby Syndrome

  • Ichthyoses, Lamellar

  • Nbie

  • Nonbullous Ichthyosiform Erythroderma

  • Classic Lamellar Ichthyosis

  • Ichthyosiform Erythroderma Nonbullous Congenital

  • Ichthyosiform Erythroderma Congenital

  • Ichthyosis, Congenital, Autosomal Recessive

  • Ichthyosiform Erythroderma, Congenital

  • Collodion Fetus

  • Non-Bullous Ichthyosiform Erythroderma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13713 SPRR1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SPRR1A MGD MGI:106660
Rattus norvegicus SPRR1A RGD RGD:1593163
Others SPRR1A NCBI