GLIS1 - GLIS family zinc finger 1 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 148979

About GLIS1

Cytogenetic location: 1p32.3 Genomic coordinates (GRCh38): 1:53,506,239-53,739,164 (from NCBI)

This gene has 2 transcripts (splice variants), 196 orthologues and 14 paralogues. Low expression observed in reference dataset.

Summary

GLIS1 is a Gli (MIM 165220)-related Kruppel-like Zinc Finger Protein that functions as an activator and repressor of transcription (Kim et al., 2002 [PubMed 12042312]).[supplied by OMIM, Mar 2008]

GLIS1 Products (5)

mRNA Protein Name
NM_001367484.1 NP_001354413.1 zinc finger protein GLIS1 isoform 2
NM_001390836.1 NP_001377765.1 zinc finger protein GLIS1 isoform 3
NM_001390837.1 NP_001377766.1 zinc finger protein GLIS1 isoform 2
NM_001390838.1 NP_001377767.1 zinc finger protein GLIS1 isoform 4
NM_147193.4 NP_671726.2 zinc finger protein GLIS1 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GLIS1 Protein Structure

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (249 - 275)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (278 - 305)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (322 - 346)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 620 a.a.
Protein Preferred Names Protein Names

zinc finger protein GLIS1

  • GLI-similar 1

GLIS1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GLIS1 Q8NBF1 ZDHHC23 Homo sapiens Q8IYP9
Y2H Array
32296183
Intra
GLIS1 Q8NBF1 ZDHHC23 Homo sapiens Q8IYP9
Y2H Prey Pooling
32296183
Intra
GLIS1 Q8NBF1 SPRR1A Homo sapiens P35321
Y2H Prey Pooling
32296183
Intra
GLIS1 Q8NBF1 SPRR1A Homo sapiens P35321
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Venezuelan Equine Encephalitis

  • Venezuelan Equine Fever

  • Venezuelan Equine Encephalomyelitis

  • Encephalitis Venezuelan Equine

  • Encephalomyelitis, Venezuelan Equine

  • Venezuelan Encephalitis

  • Disorder Due To Venezuelan Equine Encephalitis Virus

  • Venezuelan Equine Encephalitis Virus Infection

  • Venezuelan Equine Encephalomyelitis Virus Disease
Myoclonic Epilepsy Associated With Ragged-Red Fibers

  • Merrf Syndrome

  • MERRF

  • Fukuhara Syndrome

  • Myoclonic Epilepsy Associated With Ragged Red Fibers

  • Myoencephalopathy Ragged-Red Fiber Disease

  • Myoclonic Epilepsy - Ragged Red Fibers

  • Myoclonus Epilepsy And Ragged Red Fibers

  • Myoclonus With Epilepsy And With Ragged Red Fibers

  • Myoclonic Epilepsy With Ragged Red Fibers

  • Myoclonic Epilepsy With Ragged-Red Fibers

  • Fukuhara Disease

  • Myoclonus Epilepsy Associated With Ragged-Red Fibres

  • Myoclonus With Epilepsy With Ragged Red Fibers
Congenital Hypothyroidism

  • Cretinism

  • Neonatal Hypothyroidism

  • Ch

  • Cht

  • Congenital Myxedema

  • Myxedema, Congenital

  • Endemic Cretinism

  • Congenital Iodine-Deficiency Syndrome

  • Fetal Iodine Deficiency Syndrome

  • Congenital Iodine-Deficiency Hypothyroidism Nos
Nephronophthisis

  • Medullary Cystic Disease

  • Medullary Cystic Kidney

  • Nph

  • Nphp

  • Kidney Disease, Cystic, Medullary
Parkinson Disease, Late-Onset

  • Parkinson Disease

  • Parkinson'S Disease

  • PD

  • PARK

  • Parkinson Disease, Susceptibility To

  • Late Onset Parkinson'S Disease

  • Late Onset Parkinson Disease

  • Paralysis Agitans

  • Primary Parkinsonism

  • Idiopathic Parkinson Disease

  • Parkinson'S

  • Parkinson Disease, Late-Onset, Susceptibility To

  • Parkinson Disease, Age Of Onset, Modifier

  • Lewy Body Parkinson Disease

  • Idiopathic Parkinson'S Disease

  • Pd - [Parkinson Disease]

  • Parkinson Disease Nos

  • Parkinson, Nos

  • Primary Parkinson Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-13242 Taladegib Inhibitor 99.92% Phase 2

Pre-clinical Phase

Bioactive Molecules (30)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13901 GANT 61 99.80% Unkown
HY-P4860 Adropin (34-76) (human, mouse, rat) 98.23% Unkown
HY-13282 GANT 58 Antagonist 99.37% Unkown
HY-N2112 Glaucocalyxin A 99.88% Unkown
HY-18366A RU-SKI 43 hydrochloride Inhibitor 98.81% Unkown
HY-122590 Glabrescione B Inhibitor 98.08% Unkown
HY-107551 Hh Pathway-IN-1 99.06% Unkown
HY-107408 SANT 2 Antagonist 99.41% Unkown
HY-W111144 T-1330 Inhibitor / Unkown
HY-18366 RU-SKI 43 Inhibitor / Unkown
HY-RS05472 GLI1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-13242A Taladegib hydrochloride Inhibitor / Unkown
HY-137567 Prostaglandin E1 ethanolamide Activator / Unkown
HY-143400 HSP70-IN-3 Inhibitor / Unkown
HY-147670 TPB15 / Unkown
HY-159893 SMO-IN-5 / Unkown
HY-161459 GLI1-IN-1 / Unkown
HY-162273 Antibacterial agent 189 Inhibitor / Unkown
HY-176056 Hedgehog IN-9 / Unkown
HY-182641 SAG analog (cis-isomer) Activator / Unkown
HY-183335 SMO-IN-6 / Unkown
HY-N8270 Physalin H Inhibitor / Unkown
HY-N9684 Degalactotigonin / Unkown
HY-RS05473 Gli1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05474 Gli1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05480 GLIS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-122017 Methoxy-SANT-2 Antagonist / Unkown
HY-13901R GANT 61 (Standard) / Unkown
HY-172449 GLI1-IN-3 Inhibitor / Unkown
HY-W338819 Clobetasol / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus GLIS1 VGNC VGNC:62580
Mus musculus GLIS1 MGD MGI:2386723
Rattus norvegicus GLIS1 RGD RGD:1308030
Macaca mulatta GLIS1 VGNC VGNC:73034
Canis familiaris GLIS1 VGNC VGNC:49872
Bos taurus GLIS1 VGNC VGNC:29406
Others GLIS1 NCBI