TPM4 - tropomyosin 4 Gene

Also Known as HEL-S-108

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7171

About TPM4

Cytogenetic location: 19p13.12-p13.11 Genomic coordinates (GRCh38): 19:16,067,538-16,103,002 (from NCBI)

This gene has 35 transcripts (splice variants), 258 orthologues, 3 paralogues and is associated with 54 phenotypes. Ubiquitous expression in gall bladder (RPKM 102.4), urinary bladder (RPKM 100.5) and 25 other tissues.

Summary

This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the Cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of Other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of Myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]

TPM4 Products (5)

mRNA Protein Name
NM_001145160.2 NP_001138632.1 tropomyosin alpha-4 chain isoform Tpm4.1cy
NM_001367836.1 NP_001354765.1 tropomyosin alpha-4 chain isoform 3
NM_001367837.2 NP_001354766.1 tropomyosin alpha-4 chain isoform 4
NM_001367838.1 NP_001354767.1 tropomyosin alpha-4 chain isoform 5
NM_003290.3 NP_003281.1 tropomyosin alpha-4 chain isoform Tpm4.2cy

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
24407287 GOA
Biological Process GO Annotation Evidence References Source
involved in platelet formation IMP
IMP: Inferred from mutant phenotype
28134622 GOA
Cellular Component GO Annotation Evidence References Source
located in stress fiber IDA
IDA: Inferred from direct assay
16236705 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TPM4 Protein Structure

Tropomyosin

Tropomyosin: Tropomyosin (12 - 247)

  • 0
  • 100
  • 200
  • 248 a.a.
Protein Preferred Names Protein Names

tropomyosin alpha-4 chain

  • TM30p1

TPM4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TPM4 P67936 JRK Homo sapiens O75564-2
Y2H Prey Pooling
32296183
Intra
TPM4 P67936 JRK Homo sapiens O75564-2
Y2H Array
32296183
Intra
TPM4 P67936 SNAPIN Homo sapiens O95295
Y2H Array
32296183
Intra
TPM4 P67936 SNAPIN Homo sapiens O95295
Y2H Prey Pooling
32296183
Intra
TPM4 P67936 TPM3 Homo sapiens P06753
Anti Tag CoIP
33961781
Intra
TPM4 P67936 TPM3 Homo sapiens P06753
Y2H Array
32296183
Intra
TPM4 P67936 TPM3 Homo sapiens P06753
Y2H Prey Pooling
32296183
Intra
TPM4 P67936 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra
TPM4 P67936 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra
TPM4 P67936 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TPM4 Proteins

Cat. No. Product Name Accession Purity
HY-P76111 TPM4 Protein, Human (HEK293, His) P67936 (A2-I248) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Inflammatory Myofibroblastic Tumor

  • Inflammatory Fibrosarcoma
Autosomal Dominant Macrothrombocytopenia
Epithelioid Inflammatory Myofibroblastic Sarcoma
Arthrogryposis, Distal, Type 1a

  • Distal Arthrogryposis Type 1

  • Digitotalar Dysmorphism

  • DA1A

  • Da1

  • Amcd1

  • Arthrogryposis, Distal, Type 2b4

  • Distal Arthrogryposis Type 1a

  • Arthrogryposis, Distal, Type 1

  • Arthrogryposis Multiplex Congenita Distal Type 1

  • Arthrogryposis Multiplex Congenita, Distal Type 1

  • Arthrogryposis Multiplex Congenita, Distal, Type I

  • Distal Arthrogryposis Type 1b

  • Arthrogryposis, Distal, 1a

  • Amc

  • Arthrogryposis Multiplex Congenita

  • Arthrogryposis, Distal, 2b4

  • DA2B4

  • Arthrogryposis Multiplex Congenita, Distal, Type 1

  • Arthrogryposis
Mesenchymal Cell Neoplasm

  • Benign Miscellaneous Mesenchymal Tumor

  • Mesenchymal Tumor

  • Mesenchymal Tumors
Pseudosarcomatous Fibromatosis

  • Nodular Fasciitis

  • Pseudosarcomatous Fasciitis

  • Fasciitis - Nodular

  • Fasciitis Nodular
Cardiomyopathy, Familial Hypertrophic, 1

  • Asymmetric Septal Hypertrophy

  • Familial Hypertrophic Cardiomyopathy

  • Hypertrophic Cardiomyopathy 1

  • CMH1

  • Hypertrophic Cardiomyopathy 19

  • CMH

  • Ventricular Hypertrophy, Hereditary

  • Ash

  • Hypertrophic Subaortic Stenosis, Idiopathic

  • Cardiomyopathy, Familial Hypertrophic

  • Cardiomyopathy, Hypertrophic, 1, Digenic

  • Cardiomyopathy, Familial Hypertrophic 1

  • Hcm

  • Hereditary Ventricular Hypertrophy

  • Idiopathic Hypertrophic Subaortic Stenosis

  • Hypertrophic Cardiomyopathy

  • Cardiomyopathy, Hypertrophic, Familial

  • Cardiomyopathy, Hypertrophic, 1

  • Familial Asymmetric Septal Hypertrophy

  • Heritable Hypertrophic Cardiomyopathy

  • Fhc

  • Cardiomyopathy, Hypertrophic, Familial, Type 1
Hypertrophic Cardiomyopathy

  • Hypertrophic Obstructive Cardiomyopathy

  • Cardiomyopathy, Hypertrophic

  • Cardiomyopathy Hypertrophic Obstructive

  • Cardiomyopathy, Hypertrophic, Familial

  • Idiopathic Myocardial Hypertrophy

  • Idiopathic Hypertrophic Cardiomyopathy

  • Obstructive Idiopathic Hypertrophic Cardiomyopathy

  • Obstructive Cardiomyopathy

  • Idiopathic Hypertrophic Subaortic Stenosis

  • Muscular Subaortic Stenosis

  • Hypertrophic Obstructive Subaortic Stenosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-108440 Shz-1 99.88% Unkown
HY-RS14939 TPM4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18642 Tpm4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25127 Tpm4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TPM4 VGNC VGNC:66478
Rattus norvegicus TPM4 RGD RGD:3899
Canis familiaris TPM4 VGNC VGNC:47744
Bos taurus TPM4 VGNC VGNC:36254
Mus musculus TPM4 MGD MGI:2449202
Others TPM4 NCBI