TPM4 - tropomyosin 4 Gene

Homo sapiens

Also known as HEL-S-108

Gene ID: 7171 | Gene type: protein coding

About TPM4

Cytogenetic location: 19p13.12-p13.11 Genomic coordinates (GRCh38): 19:16,067,538-16,103,002 (from NCBI)

This gene has 35 transcripts (splice variants), 258 orthologues, 3 paralogues and is associated with 54 phenotypes. Ubiquitous expression in gall bladder (RPKM 102.4), urinary bladder (RPKM 100.5) and 25 other tissues.

Summary

This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the Cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of Myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]

TPM4 Products(5)

mRNA	Protein	Name
NM_001145160.2	NP_001138632.1	tropomyosin alpha-4 chain isoform Tpm4.1cy
NM_001367836.1	NP_001354765.1	tropomyosin alpha-4 chain isoform 3
NM_001367837.2	NP_001354766.1	tropomyosin alpha-4 chain isoform 4
NM_001367838.1	NP_001354767.1	tropomyosin alpha-4 chain isoform 5
NM_003290.3	NP_003281.1	tropomyosin alpha-4 chain isoform Tpm4.2cy

TPM4 Protein Structure

Tropomyosin

0
100
200
248 a.a.

Protein Preferred Names

Protein Names

tropomyosin alpha-4 chain

TM30p1

Recombinant TPM4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76111	TPM4 Protein, Human (HEK293, His)	P67936 (A2-I248)	≥95%

Related Diseases

Diseases

Alias

Inflammatory Myofibroblastic Tumor

Inflammatory Fibrosarcoma

Autosomal Dominant Macrothrombocytopenia

Epithelioid Inflammatory Myofibroblastic Sarcoma

Arthrogryposis, Distal, Type 1a

Distal Arthrogryposis Type 1	Digitotalar Dysmorphism
DA1A	Da1
Amcd1	Arthrogryposis, Distal, Type 2b4
Distal Arthrogryposis Type 1a	Arthrogryposis, Distal, Type 1
Arthrogryposis Multiplex Congenita Distal Type 1	Arthrogryposis Multiplex Congenita, Distal Type 1
Arthrogryposis Multiplex Congenita, Distal, Type I	Distal Arthrogryposis Type 1b
Arthrogryposis, Distal, 1a	Amc
Arthrogryposis Multiplex Congenita	Arthrogryposis, Distal, 2b4
DA2B4	Arthrogryposis Multiplex Congenita, Distal, Type 1
Arthrogryposis

Mesenchymal Cell Neoplasm

Benign Miscellaneous Mesenchymal Tumor	Mesenchymal Tumor
Mesenchymal Tumors

Pseudosarcomatous Fibromatosis

Nodular Fasciitis	Pseudosarcomatous Fasciitis
Fasciitis - Nodular	Fasciitis Nodular

Cardiomyopathy, Familial Hypertrophic, 1

Asymmetric Septal Hypertrophy	Familial Hypertrophic Cardiomyopathy
Hypertrophic Cardiomyopathy 1	CMH1
Hypertrophic Cardiomyopathy 19	CMH
Ventricular Hypertrophy, Hereditary	Ash
Hypertrophic Subaortic Stenosis, Idiopathic	Cardiomyopathy, Familial Hypertrophic
Cardiomyopathy, Hypertrophic, 1, Digenic	Cardiomyopathy, Familial Hypertrophic 1
Hcm	Hereditary Ventricular Hypertrophy
Idiopathic Hypertrophic Subaortic Stenosis	Hypertrophic Cardiomyopathy
Cardiomyopathy, Hypertrophic, Familial	Cardiomyopathy, Hypertrophic, 1
Familial Asymmetric Septal Hypertrophy	Heritable Hypertrophic Cardiomyopathy
Fhc	Cardiomyopathy, Hypertrophic, Familial, Type 1

Hypertrophic Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy	Cardiomyopathy, Hypertrophic
Cardiomyopathy Hypertrophic Obstructive	Cardiomyopathy, Hypertrophic, Familial
Idiopathic Myocardial Hypertrophy	Idiopathic Hypertrophic Cardiomyopathy
Obstructive Idiopathic Hypertrophic Cardiomyopathy	Obstructive Cardiomyopathy
Idiopathic Hypertrophic Subaortic Stenosis	Muscular Subaortic Stenosis
Hypertrophic Obstructive Subaortic Stenosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108440	Shz-1		99.88%	Unkown
HY-RS14939	TPM4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TPM4	VGNC	VGNC:66478
Rattus norvegicus	TPM4	RGD	RGD:3899
Canis familiaris	TPM4	VGNC	VGNC:47744
Bos taurus	TPM4	VGNC	VGNC:36254
Mus musculus	TPM4	MGD	MGI:2449202
Others	TPM4	NCBI

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