2. Gene
  3. Mir17 - microRNA 17 Gene

Mir17 - microRNA 17 Gene

  • Gene
  • Agent
  • Ortholog
Mus musculus

Also known as Mirn17; mir-17; mmu-mir-17

Gene ID: 723905 | Gene type: ncRNA

About Mir17

Summary

MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within B cell apoptotic process IGI
IGI: Inferred from genetic interaction
18329372 MGI
acts upstream of or within cellular response to decreased oxygen levels IEP
IEP: Inferred from expression pattern
19147652 MGI
acts upstream of or within cellular response to forskolin IEP
IEP: Inferred from expression pattern
21993888 MGI
acts upstream of or within in utero embryonic development IGI
IGI: Inferred from genetic interaction
18329372 MGI
acts upstream of or within long-term synaptic potentiation IEP
IEP: Inferred from expression pattern
25858512 MGI
acts upstream of or within lung development IGI
IGI: Inferred from genetic interaction
18329372 MGI
acts upstream of or within miRNA-mediated post-transcriptional gene silencing IMP
IMP: Inferred from mutant phenotype
21338882 MGI
acts upstream of or within multicellular organismal-level iron ion homeostasis IDA
IDA: Inferred from direct assay
21364282 MGI
acts upstream of or within negative regulation of apoptotic process IGI
IGI: Inferred from genetic interaction
18329372 MGI
acts upstream of or within pre-B cell differentiation IGI
IGI: Inferred from genetic interaction
18329372 MGI
acts upstream of or within response to bacterium IEP
IEP: Inferred from expression pattern
24205035 MGI
acts upstream of or within response to wounding IEP
IEP: Inferred from expression pattern
24205035 MGI
acts upstream of or within sensory perception of sound IEP
IEP: Inferred from expression pattern
23646144 MGI
acts upstream of or within spinal cord motor neuron differentiation IGI
IGI: Inferred from genetic interaction
21338882 MGI
acts upstream of or within spinal cord motor neuron differentiation IMP
IMP: Inferred from mutant phenotype
21338882 MGI
acts upstream of or within ventricular septum morphogenesis IGI
IGI: Inferred from genetic interaction
18329372 MGI
Cellular Component GO Annotation Evidence Reference Source
part of RISC complex IDA
IDA: Inferred from direct assay
23185045 MGI
located in extracellular exosome IDA
IDA: Inferred from direct assay
24205035 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-150364A Farabursen sodium Inhibitor 93.56% Phase 3
HY-139290A RGLS4326 sodium 99.67% Phase 1
Pre-clinical Phase
Bioactive Molecules (23)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-139290 RGLS4326 99.06% Unkown
HY-150364 Farabursen 97.59% Unkown
HY-R00326 hsa-miR-17-5p mimic 99.82% Unkown
HY-RI00326 hsa-miR-17-5p inhibitor 99.58% Unkown
HY-RI00326A hsa-miR-17-5p antagomir 99.58% Unkown
HY-R00326A hsa-miR-17-5p agomir / Unkown
HY-RI02695 mmu-miR-17-3p inhibitor 92.65% Unkown
HY-179344 Benzazepinoquinoline-spermine Inhibitor / Unkown
HY-R00325 hsa-miR-17-3p mimic / Unkown
HY-R00325A hsa-miR-17-3p agomir / Unkown
HY-R02695 mmu-miR-17-3p mimic / Unkown
HY-R02695A mmu-miR-17-3p agomir / Unkown
HY-R04249 rno-miR-17-1-3p mimic / Unkown
HY-R04249A rno-miR-17-1-3p agomir / Unkown
HY-R04250 rno-miR-17-2-3p mimic / Unkown
HY-R04250A rno-miR-17-2-3p agomir / Unkown
HY-RI00325 hsa-miR-17-3p inhibitor / Unkown
HY-RI00325A hsa-miR-17-3p antagomir / Unkown
HY-RI02695A mmu-miR-17-3p antagomir / Unkown
HY-RI04249 rno-miR-17-1-3p inhibitor / Unkown
HY-RI04249A rno-miR-17-1-3p antagomir / Unkown
HY-RI04250 rno-miR-17-2-3p inhibitor / Unkown
HY-RI04250A rno-miR-17-2-3p antagomir / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mir17 NCBI NCBI:406952