2. Gene
  3. Insig2 - insulin induced gene 2 Gene

Insig2 - insulin induced gene 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Insig-2; 2900053I11Rik; C730043J18Rik

Gene ID: 72999 | Gene type: protein coding

About Insig2

Summary

Predicted to enable oxysterol binding activity. Acts upstream of or within several processes, including Cholesterol biosynthetic process; ear morphogenesis; and negative regulation of lipid biosynthetic process. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of SREBP-SCAP-Insig complex. Predicted to be active in endoplasmic reticulum. Is expressed in central nervous system; jaw bone; and retina. Orthologous to human INSIG2 (Insulin induced gene 2). [provided by Alliance of Genome Resources, Apr 2022]

Insig2 Products(5)

mRNA Protein Name
NM_001271531.1 NP_001258460.1 insulin-induced gene 2 protein isoform 1
NM_001271532.1 NP_001258461.1 insulin-induced gene 2 protein isoform 2
NM_001357251.1 NP_001344180.1 insulin-induced gene 2 protein isoform 1
NM_133748.2 NP_598509.1 insulin-induced gene 2 protein isoform 1
NM_178082.3 NP_835183.1 insulin-induced gene 2 protein isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
12242332 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cholesterol biosynthetic process IGI
IGI: Inferred from genetic interaction
16955138 MGI
acts upstream of or within cholesterol metabolic process IGI
IGI: Inferred from genetic interaction
16100574 MGI
acts upstream of or within cranial suture morphogenesis IGI
IGI: Inferred from genetic interaction
16955138 MGI
acts upstream of or within inner ear morphogenesis IGI
IGI: Inferred from genetic interaction
16955138 MGI
acts upstream of or within middle ear morphogenesis IGI
IGI: Inferred from genetic interaction
16955138 MGI
acts upstream of or within negative regulation of fatty acid biosynthetic process IGI
IGI: Inferred from genetic interaction
16100574 MGI
acts upstream of or within negative regulation of steroid biosynthetic process IGI
IGI: Inferred from genetic interaction
16100574 MGI
acts upstream of or within response to sterol depletion IDA
IDA: Inferred from direct assay
12354157 MGI
acts upstream of or within roof of mouth development IGI
IGI: Inferred from genetic interaction
16955138 MGI
acts upstream of or within sterol biosynthetic process IGI
IGI: Inferred from genetic interaction
16955138 MGI
acts upstream of or within triglyceride metabolic process IGI
IGI: Inferred from genetic interaction
16100574 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

insulin-induced gene 2 protein

INSIG-2 membrane protein

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06838 INSIG2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Insig2 NCBI NCBI:51141