Sgip1 - SH3-domain GRB2-like (endophilin) interacting protein 1 Gene

Also Known as gag; SGIP1alpha; 3110007P09Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 73094

Summary

Enables microtubule binding activity and phospholipid binding activity. Acts upstream of or within plasma membrane tubulation and positive regulation of receptor-mediated endocytosis. Located in clathrin-coated vesicle and plasma membrane. Part of AP-2 adaptor complex. Is expressed in central nervous system; metanephros; small intestine; and testis. Orthologous to human SGIP1 (SH3GL interacting endocytic adaptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Sgip1 Products (5)

mRNA	Protein	Name
NM_001285852.1	NP_001272781.1	SH3-containing GRB2-like protein 3-interacting protein 1 isoform a
NM_001285859.1	NP_001272788.1	SH3-containing GRB2-like protein 3-interacting protein 1 isoform c
NM_001285860.1	NP_001272789.1	SH3-containing GRB2-like protein 3-interacting protein 1 isoform d
NM_001285862.1	NP_001272791.1	SH3-containing GRB2-like protein 3-interacting protein 1 isoform e
NM_144906.2	NP_659155.1	SH3-containing GRB2-like protein 3-interacting protein 1 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables microtubule binding	IDA IDA: Inferred from direct assay	17626015	MGI
enables phospholipid binding	IDA IDA: Inferred from direct assay	17626015	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17626015	MGI
enables tubulin binding	IPI IPI: Inferred from physical interaction	17626015	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of receptor-mediated endocytosis	IMP IMP: Inferred from mutant phenotype	17626015	MGI
involved in synaptic vesicle endocytosis	IDA IDA: Inferred from direct assay	31053155	MGI
involved in synaptic vesicle endocytosis	IEP IEP: Inferred from expression pattern	31053155	MGI
involved in synaptic vesicle endocytosis	IMP IMP: Inferred from mutant phenotype	31053155	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of AP-2 adaptor complex	IDA IDA: Inferred from direct assay	17626015	MGI
located in clathrin-coated vesicle	IDA IDA: Inferred from direct assay	17626015	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	17626015	MGI
is active in presynapse	IDA IDA: Inferred from direct assay	31053155	MGI
is active in presynapse	IMP IMP: Inferred from mutant phenotype	31053155	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
SH3-containing GRB2-like protein 3-interacting protein 1	SH3-domain GRB2-like interacting protein 1 alpha endophilin-3-interacting protein

Sgip1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Sgip1	Q8VD37	Canx	Mus musculus	P35564	Anti Bait CoIP	21747946
Intra	Sgip1	Q8VD37	Canx	Mus musculus	P35564	Confocal	21747946
Cross	Sgip1	Q8VD37	Eps15	Rattus norvegicus	A7BFV9	Y2H	17626015
Cross	Sgip1	Q8VD37	Eps15	Rattus norvegicus	A7BFV9	Pull Down	17626015

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12797	SGIP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sgip1	NCBI	NCBI:84251