UBE2G2 - ubiquitin conjugating enzyme E2 G2 Gene

Also Known as UBC7

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7327

About UBE2G2

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:44,768,580-44,801,820 (from NCBI)

This gene has 12 transcripts (splice variants), 197 orthologues and 24 paralogues. Ubiquitous expression in spleen (RPKM 19.6), appendix (RPKM 19.0) and 25 other tissues.

Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating Enzymes, or E1s, ubiquitin-conjugating Enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse counterpart. This gene is ubiquitously expressed, with high expression seen in adult muscle. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

UBE2G2 Products (3)

mRNA	Protein	Name
NM_001202489.2	NP_001189418.1	ubiquitin-conjugating enzyme E2 G2 isoform 3
NM_003343.6	NP_003334.2	ubiquitin-conjugating enzyme E2 G2 isoform 1
NM_182688.3	NP_872630.1	ubiquitin-conjugating enzyme E2 G2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16407162	GOA
enables ubiquitin conjugating enzyme activity	IDA IDA: Inferred from direct assay	20061386	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	20061386	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in ERAD pathway	IMP IMP: Inferred from mutant phenotype	22607976	GOA
involved in cellular response to interferon-beta	IMP IMP: Inferred from mutant phenotype	24882218	GOA
involved in negative regulation of retrograde protein transport, ER to cytosol	IMP IMP: Inferred from mutant phenotype	25660456	GOA
involved in protein K48-linked ubiquitination	IDA IDA: Inferred from direct assay	20061386	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	23223569	GOA
located in lipid droplet	IDA IDA: Inferred from direct assay	21127063	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBE2G2 Protein Structure

UQ_con

0
100
165 a.a.

Protein Preferred Names	Protein Names
ubiquitin-conjugating enzyme E2 G2	E2 ubiquitin-conjugating enzyme G2

UBE2G2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	UBE2G2	P60604	AMFR	Homo sapiens	Q9UKV5	NMR	23942235
Intra	UBE2G2	P60604	AMFR	Homo sapiens	Q9UKV5	SPR	23942235
Intra	UBE2G2	P60604	AUP1	Homo sapiens	Q9Y679	Anti Bait CoIP	17353931
Intra	UBE2G2	P60604	AUP1	Homo sapiens	Q9Y679	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant UBE2G2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71401	UBE2G2 Protein, Human (GST)	P60604 (M1-L165)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Machado-Joseph Disease	SCA3 MJD Spinocerebellar Ataxia 3 Azorean Disease Spinocerebellar Ataxia Type 3 Spinocerebellar Atrophy Azorean Neurologic Disease Spinopontine Atrophy Nigrospinodentatal Degeneration Spinocerebellar Atrophy Iii Spinocerebellar Atrophy Type 3 Azorean Ataxia Azorean Disease Of The Nervous System Machado Disease Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia Disease, Machado-Joseph Ataxia, Spinocerebellar

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15347	UBE2G2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19534	Ube2g2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26030	Ube2g2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	UBE2G2	VGNC	VGNC:36582
Rattus norvegicus	UBE2G2	RGD	RGD:1304860
Canis familiaris	UBE2G2	VGNC	VGNC:48053
Mus musculus	UBE2G2	MGD	MGI:1343188
Others	UBE2G2	NCBI