AMFR - autocrine motility factor receptor Gene
Also Known as GP78; RNF45
Species: Homo sapiens
About AMFR
This gene has 12 transcripts (splice variants), 233 orthologues and 4 paralogues. Ubiquitous expression in testis (RPKM 45.4), kidney (RPKM 36.4) and 25 other tissues.
Summary
This locus encodes a glycosylated transmembrane receptor. Its ligand, autocrine motility factor, is a tumor motility-stimulating protein secreted by tumor cells. The encoded receptor is also a member of the E3 ubiquitin Ligase family of proteins. It catalyzes ubiquitination and endoplasmic reticulum-associated degradation of specific proteins. [provided by RefSeq, Feb 2012]
AMFR Products (3)
| mRNA | Protein | Name |
|---|---|---|
| NM_001144.6 | NP_001135.3 | E3 ubiquitin-protein ligase AMFR isoform c |
| NM_001323511.2 | NP_001310440.1 | E3 ubiquitin-protein ligase AMFR isoform e |
| NM_001323512.2 | NP_001310441.1 | E3 ubiquitin-protein ligase AMFR isoform d |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| part of Derlin-1 retrotranslocation complex |
IDA
IDA: Inferred from direct assay
|
17872946 | GOA |
| located in endoplasmic reticulum |
IDA
IDA: Inferred from direct assay
|
22728137 | GOA |
| located in endoplasmic reticulum membrane |
IDA
IDA: Inferred from direct assay
|
11724934 | GOA |
| located in endoplasmic reticulum membrane |
IMP
IMP: Inferred from mutant phenotype
|
37119330 | GOA |
| located in perinuclear region of cytoplasm |
IDA
IDA: Inferred from direct assay
|
16275660 | GOA |
| part of protein-containing complex |
IDA
IDA: Inferred from direct assay
|
23382219 | GOA |
AMFR Protein Structure
zf-RING_2: Ring finger domain (339 - 379)
CUE: CUE domain (458 - 497)
- 0
- 100
- 200
- 300
- 400
- 500
- 600
- 643 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
E3 ubiquitin-protein ligase AMFR |
|
AMFR Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
AMFR | Q9UKV5 | UBE2G2 | Homo sapiens | P60604 | 23942235 | |
|
Intra
|
AMFR | Q9UKV5 | VCP | Homo sapiens | P55072 | 16275660 | |
|
Intra
|
AMFR | Q9UKV5 | VCP | Homo sapiens | P55072 | 16407162 | |
|
Intra
|
AMFR | Q9UKV5 | VCP | Homo sapiens | P55072 | 22119785 | |
|
Intra
|
AMFR | Q9UKV5 | UBE2G2 | Homo sapiens | P60604 | 22119785 | |
|
Intra
|
AMFR | Q9UKV5 | VCP | Homo sapiens | P55072 | 21343306 | |
|
Intra
|
AMFR | Q9UKV5 | UBE2G2 | Homo sapiens | P60604 | 16407162 | |
|
Intra
|
AMFR | Q9UKV5 | VCP | Homo sapiens | P55072 | 16275660 | |
|
Intra
|
AMFR | Q9UKV5 | UBE2G2 | Homo sapiens | P60604 | 17353931 | |
|
Intra
|
AMFR | Q9UKV5 | UBE2G2 | Homo sapiens | P60604 | 23942235 | |
|
Intra
|
AMFR | Q9UKV5 | TMUB1 | Homo sapiens | Q9BVT8 | 22119785 | |
|
Intra
|
AMFR | Q9UKV5 | ERLIN1 | Homo sapiens | O75477 | 22119785 | |
|
Intra
|
AMFR | Q9UKV5 | ERLIN1 | Homo sapiens | O75477 | 21343306 | |
|
Intra
|
AMFR | Q9UKV5 | ERLIN2 | Homo sapiens | O94905 | 22119785 | |
|
Intra
|
AMFR | Q9UKV5 | ERLIN2 | Homo sapiens | O94905 | 21343306 | |
|
Intra
|
AMFR | Q9UKV5 | ERLIN2 | Homo sapiens | O94905 | 21343306 | |
|
Cross
|
AMFR | Q9UKV5 | Ube2g2 | Mus musculus | P60605 | 19223579 | |
|
Cross
|
AMFR | Q9UKV5 | Ube2g2 | Mus musculus | P60605 | 16462746 | |
|
Cross
|
AMFR | Q9UKV5 | Ube2g2 | Mus musculus | P60605 | 16407162 | |
|
Cross
|
AMFR | Q9UKV5 | Ube2g2 | Mus musculus | P60605 | 19223579 | |
|
Cross
|
AMFR | Q9UKV5 | Ube2g2 | Mus musculus | P60605 | 19223579 |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Encephalopathy, Familial, With Neuroserpin Inclusion Bodies |
|
|
| Transitional Cell Carcinoma |
|
|
| Hepatocellular Clear Cell Carcinoma |
|
|
| Spastic Paraplegia, Optic Atrophy, And Neuropathy |
|
|
| Charcot-Marie-Tooth Disease |
|
|
| Inclusion Body Myopathy With Paget Disease Of Bone And Frontotemporal Dementia |
|
|
| Lung Cancer |
|
|
| Cystic Fibrosis |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | AMFR | RGD | RGD:1311551 |
| Bos taurus | AMFR | VGNC | VGNC:25863 |
| Mus musculus | AMFR | MGD | MGI:1345634 |
| Macaca mulatta | AMFR | VGNC | VGNC:69804 |
| Canis familiaris | AMFR | VGNC | VGNC:37829 |
| Felis catus | AMFR | VGNC | VGNC:67490 |
| Others | AMFR | NCBI |