AMFR - autocrine motility factor receptor Gene

Also Known as GP78; RNF45

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 267

About AMFR

Cytogenetic location: 16q13 Genomic coordinates (GRCh38): 16:56,361,452-56,425,545 (from NCBI)

This gene has 12 transcripts (splice variants), 233 orthologues and 4 paralogues. Ubiquitous expression in testis (RPKM 45.4), kidney (RPKM 36.4) and 25 other tissues.

Summary

This locus encodes a glycosylated transmembrane receptor. Its ligand, autocrine motility factor, is a tumor motility-stimulating protein secreted by tumor cells. The encoded receptor is also a member of the E3 ubiquitin Ligase family of proteins. It catalyzes ubiquitination and endoplasmic reticulum-associated degradation of specific proteins. [provided by RefSeq, Feb 2012]

AMFR Products (3)

mRNA Protein Name
NM_001144.6 NP_001135.3 E3 ubiquitin-protein ligase AMFR isoform c
NM_001323511.2 NP_001310440.1 E3 ubiquitin-protein ligase AMFR isoform e
NM_001323512.2 NP_001310441.1 E3 ubiquitin-protein ligase AMFR isoform d
Molecular Function GO Annotation Evidence References Source
enables BAT3 complex binding IDA
IDA: Inferred from direct assay
24424410 GOA
enables BAT3 complex binding IPI
IPI: Inferred from physical interaction
21636303 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
17310145 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11724934 GOA
enables protein-folding chaperone binding IPI
IPI: Inferred from physical interaction
21636303 GOA
enables protein-macromolecule adaptor activity IMP
IMP: Inferred from mutant phenotype
24424410 GOA
enables signaling receptor activity IPI
IPI: Inferred from physical interaction
1649192 GOA
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
17310145 GOA
enables ubiquitin protein ligase activity IMP
IMP: Inferred from mutant phenotype
37119330 GOA
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
11724934 GOA
enables ubiquitin-protein transferase activity IMP
IMP: Inferred from mutant phenotype
16168377 GOA
enables ubiquitin-specific protease binding IPI
IPI: Inferred from physical interaction
24424410 GOA
enables ubiquitin-ubiquitin ligase activity IDA
IDA: Inferred from direct assay
24810856 GOA
Biological Process GO Annotation Evidence References Source
involved in ERAD pathway IDA
IDA: Inferred from direct assay
11724934 GOA
involved in ERAD pathway IMP
IMP: Inferred from mutant phenotype
16168377 GOA
involved in endoplasmic reticulum unfolded protein response IMP
IMP: Inferred from mutant phenotype
17157811 GOA
involved in negative regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
31073040 GOA
involved in non-canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
15327770 GOA
involved in protein K27-linked ubiquitination IDA
IDA: Inferred from direct assay
15327770 GOA
involved in protein K48-linked ubiquitination IDA
IDA: Inferred from direct assay
12847084 GOA
involved in protein autoubiquitination IDA
IDA: Inferred from direct assay
24810856 GOA
involved in protein polyubiquitination IDA
IDA: Inferred from direct assay
17310145 GOA
involved in protein polyubiquitination IMP
IMP: Inferred from mutant phenotype
24810856 GOA
involved in ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
16168377 GOA
Cellular Component GO Annotation Evidence References Source
part of Derlin-1 retrotranslocation complex IDA
IDA: Inferred from direct assay
17872946 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
22728137 GOA
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
11724934 GOA
located in endoplasmic reticulum membrane IMP
IMP: Inferred from mutant phenotype
37119330 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
16275660 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
23382219 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AMFR Protein Structure

zf-RING_2

zf-RING_2: Ring finger domain (339 - 379)

CUE

CUE: CUE domain (458 - 497)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 643 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase AMFR

  • RING finger protein 45

AMFR Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
AMFR Q9UKV5 UBE2G2 Homo sapiens P60604
NMR
23942235
Intra
AMFR Q9UKV5 VCP Homo sapiens P55072 16275660
Intra
AMFR Q9UKV5 VCP Homo sapiens P55072 16407162
Intra
AMFR Q9UKV5 VCP Homo sapiens P55072 22119785
Intra
AMFR Q9UKV5 UBE2G2 Homo sapiens P60604 22119785
Intra
AMFR Q9UKV5 VCP Homo sapiens P55072 21343306
Intra
AMFR Q9UKV5 UBE2G2 Homo sapiens P60604 16407162
Intra
AMFR Q9UKV5 VCP Homo sapiens P55072 16275660
Intra
AMFR Q9UKV5 UBE2G2 Homo sapiens P60604 17353931
Intra
AMFR Q9UKV5 UBE2G2 Homo sapiens P60604 23942235
Intra
AMFR Q9UKV5 TMUB1 Homo sapiens Q9BVT8 22119785
Intra
AMFR Q9UKV5 ERLIN1 Homo sapiens O75477 22119785
Intra
AMFR Q9UKV5 ERLIN1 Homo sapiens O75477 21343306
Intra
AMFR Q9UKV5 ERLIN2 Homo sapiens O94905 22119785
Intra
AMFR Q9UKV5 ERLIN2 Homo sapiens O94905 21343306
Intra
AMFR Q9UKV5 ERLIN2 Homo sapiens O94905 21343306
Cross
AMFR Q9UKV5 Ube2g2 Mus musculus P60605 19223579
Cross
AMFR Q9UKV5 Ube2g2 Mus musculus P60605 16462746
Cross
AMFR Q9UKV5 Ube2g2 Mus musculus P60605 16407162
Cross
AMFR Q9UKV5 Ube2g2 Mus musculus P60605
GMS
19223579
Cross
AMFR Q9UKV5 Ube2g2 Mus musculus P60605 19223579
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Encephalopathy, Familial, With Neuroserpin Inclusion Bodies
  • Familial Encephalopathy With Neuroserpin Inclusion Bodies

  • FENIB

  • Encephalopathy, Familial, With Collins Bodies

  • Familial Dementia With Neuroserpin Inclusion Bodies

  • Familial Encephalopathy With Collins Bodies

Transitional Cell Carcinoma
  • Transitional Cell Neoplasm

  • Carcinoma, Transitional Cell

  • Transitional Carcinoma

  • Transitional Cell Tumor

  • Urothelial Cell Carcinoma

  • Carcinoma Transitional Cell

  • Transitional Cell Carcinoma Of Bladder

Hepatocellular Clear Cell Carcinoma
  • Clear Cell Carcinoma Of The Liver Cells

  • Hepatocellular Carcinoma, Clear Cell Type

  • Clear Cell Hepatocellular Carcinoma

Spastic Paraplegia, Optic Atrophy, And Neuropathy
  • Spoan Syndrome

  • SPOAN

  • Spastic Paraplegia, Optic Atropy, And Neuropathy

  • Spastic Paraplegia, Optic Atropy, And Neuropathy Syndrome

  • Spastic Paraplegia-Optic Atrophy-Neuropathy Syndrome

Charcot-Marie-Tooth Disease
  • Cmt

  • Hmsn

  • Hereditary Motor And Sensory Neuropathy

  • Pma

  • Cmt - Charcot-Marie-Tooth Disease

  • Charcot Marie Tooth Disease

  • Charcot-Marie-Tooth Hereditary Neuropathy

  • Charcot-Marie-Tooth Syndrome

  • Peroneal Muscular Atrophy

  • Hereditary Motor And Sensory Neuropathies

Inclusion Body Myopathy With Paget Disease Of Bone And Frontotemporal Dementia
  • Ibmpfd

  • Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dementia

  • Pagetoid Amyotrophic Lateral Sclerosis

  • Pagetoid Neuroskeletal Syndrome

  • Inclusion Body Myopathy With Paget Disease Of Bone And/Or Frontotemporal Dementia

  • Inclusion Body Myopathy With Early-Onset Paget Disease Of Bone And/Or Frontotemporal Dementia

  • Multisystem Proteinopathy

  • Limb-Girdle Muscular Dystrophy With Paget Disease Of Bone

  • Inclusion Body Myopathy With Paget'S Disease Of Bone And Frontotemporal Dementia

  • Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dement

  • Lower Motor Neuron Degeneration With Paget-Like Bone Disease

  • Muscular Dystrophy, Limb-Girdle, With Paget Disease Of Bone

  • Myopathy, Inclusion Body, With Early-Onset Paget Disease And Frontotemporal Dementia

Lung Cancer
  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma

Cystic Fibrosis
  • Mucoviscidosis

  • CF

  • Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

  • Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

  • Cystic Fibrosis Lung Disease, Modifier Of

  • Cystic Fibrosis Of Pancreas

  • Fibrocystic Disease Of Pancreas

  • Cf - [Cystic Fibrosis]

  • Cystic Fibrosis Nos

  • Fibrocystic Disease

  • Fibrocystic Disease Of The Pancreas

  • Mucoviscidosis Of Pancreas

  • Nonproliferative Fibrocystic Disease

  • Pancreatic Cystic Fibrosis

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus AMFR RGD RGD:1311551
Bos taurus AMFR VGNC VGNC:25863
Mus musculus AMFR MGD MGI:1345634
Macaca mulatta AMFR VGNC VGNC:69804
Canis familiaris AMFR VGNC VGNC:37829
Felis catus AMFR VGNC VGNC:67490
Others AMFR NCBI