2. Gene
  3. Plce1 - phospholipase C, epsilon 1 Gene

Plce1 - phospholipase C, epsilon 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Plce; mKIAA1516; PLCepsilon; 4933403A21Rik

Gene ID: 74055 | Gene type: protein coding

About Plce1

Summary

Predicted to enable phosphatidylinositol Phospholipase C activity and small GTPase binding activity. Predicted to be involved in several processes, including diacylglycerol biosynthetic process; intracellular signal transduction; and regulation of signal transduction. Predicted to act upstream of or within lipid catabolic process and signal transduction. Predicted to be located in cytosol; lamellipodium; and plasma membrane. Is expressed in several structures, including facial bone primordium; heart; liver; nervous system; and thymus. Human ortholog(s) of this gene implicated in nephrotic syndrome; nephrotic syndrome type 2; and nephrotic syndrome type 3. Orthologous to human PLCE1 (Phospholipase C epsilon 1). [provided by Alliance of Genome Resources, Apr 2022]

Plce1 Products(1)

mRNA Protein Name
NM_019588.2 NP_062534.2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
23540699 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1

PLC-epsilon-1

phosphoinositide phospholipase C-epsilon-1

Plce1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Plce1 Q8K4S1 Ryr2 Mus musculus E9Q401
Anti Bait CoIP
23540699
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10659 PLCE1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Plce1 NCBI NCBI:51196