Rnf6 - ring finger protein (C3H2C3 type) 6 Gene

Also Known as 1200013I08Rik; 5730419H05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 74132

Summary

Enables DNA binding activity and ubiquitin protein Ligase activity. Involved in protein K48-linked ubiquitination. Acts upstream of or within negative regulation of axon extension; positive regulation of transcription, DNA-templated; and ubiquitin-dependent protein catabolic process. Located in PML body; axon; and cytoplasm. Is expressed in genitourinary system. Human ortholog(s) of this gene implicated in esophageal Cancer and squamous cell carcinoma. Orthologous to human RNF6 (ring finger protein 6). [provided by Alliance of Genome Resources, Apr 2022]

Rnf6 Products (4)

mRNA Protein Name
NM_001256085.1 NP_001243014.1 E3 ubiquitin-protein ligase RNF6 isoform 1
NM_001256086.1 NP_001243015.1 E3 ubiquitin-protein ligase RNF6 isoform 2
NM_001256087.1 NP_001243016.1 E3 ubiquitin-protein ligase RNF6 isoform 1
NM_028774.3 NP_083050.1 E3 ubiquitin-protein ligase RNF6 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
11971979 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16204183 MGI
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
16204183 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of axon extension IGI
IGI: Inferred from genetic interaction
16204183 MGI
acts upstream of axon extension IMP
IMP: Inferred from mutant phenotype
16204183 MGI
acts upstream of or within negative regulation of axon extension IGI
IGI: Inferred from genetic interaction
16204183 MGI
acts upstream of or within negative regulation of axon extension IMP
IMP: Inferred from mutant phenotype
16204183 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
11971979 MGI
involved in protein K48-linked ubiquitination IMP
IMP: Inferred from mutant phenotype
16204183 MGI
acts upstream of or within ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
16204183 MGI
involved in ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
36088389 MGI
Cellular Component GO Annotation Evidence References Source
located in PML body IDA
IDA: Inferred from direct assay
11971979 MGI
located in axon IDA
IDA: Inferred from direct assay
16204183 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
16204183 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase RNF6

  • RING-type E3 ubiquitin transferase RNF6

  • RLIM-like protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12095 RNF6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rnf6 NCBI NCBI:6049