Crtc2 - CREB regulated transcription coactivator 2 Gene

Also Known as Torc2; 4632407F12Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 74343

Summary

Predicted to enable cAMP response element binding protein binding activity and chromatin binding activity. Involved in gluconeogenesis; glucose homeostasis; and positive regulation of CREB transcription factor activity. Acts upstream of or within histone H3-K9 acetylation; positive regulation of transcription by RNA polymerase II; and toxin transport. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; ear; integumental system; limb; and nervous system. Orthologous to human CRTC2 (CREB regulated transcription coactivator 2). [provided by Alliance of Genome Resources, Apr 2022]

Crtc2 Products (2)

mRNA Protein Name
NM_001357152.2 NP_001344081.1 CREB-regulated transcription coactivator 2 isoform 2
NM_028881.4 NP_083157.1 CREB-regulated transcription coactivator 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17805301 MGI
Biological Process GO Annotation Evidence References Source
involved in gluconeogenesis IDA
IDA: Inferred from direct assay
16148943 MGI
involved in glucose homeostasis IMP
IMP: Inferred from mutant phenotype
16308421 MGI
involved in positive regulation of CREB transcription factor activity IDA
IDA: Inferred from direct assay
16148943 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
24674967 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
24051374 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16148943 MGI
located in nucleus IDA
IDA: Inferred from direct assay
16148943 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

CREB-regulated transcription coactivator 2

  • TORC-2

  • transducer of CREB protein 2

  • transducer of regulated cAMP response element-binding protein 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N10319 Artepillin C 99.07% Unkown
HY-RS03201 CRTC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-101149 YKL-05-093 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Crtc2 NCBI NCBI:200186