2. Immunology/Inflammation Epigenetics Cell Cycle/DNA Damage NF-κB
  3. Salt-inducible Kinase (SIK) HDAC RANKL/RANK
  4. YKL-05-093

YKL-05-093 is a salt-induced kinase (SIK) inhibitor (SIK2: Kd = 7.1 nM). YKL-05-093 reduces the phosphorylation level of HDAC4/5/CRTC2, inhibits SOST expression, and stimulates RANKL expression in vitro and in vivo. YKL-05-093 can be used in research on bone diseases.

For research use only. We do not sell to patients.

YKL-05-093

YKL-05-093 Chemical Structure

CAS No. : 2172616-44-1

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YKL-05-093 Related Antibodies

Top Publications Citing Use of Products

View All Salt-inducible Kinase (SIK) Isoform Specific Products:

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SIK1 SIK2 SIK3

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Description

YKL-05-093 is a salt-induced kinase (SIK) inhibitor (SIK2: Kd = 7.1 nM). YKL-05-093 reduces the phosphorylation level of HDAC4/5/CRTC2, inhibits SOST expression, and stimulates RANKL expression in vitro and in vivo. YKL-05-093 can be used in research on bone diseases[1].

Molecular Weight

608.73

Formula

C35H40N6O4
CAS No.
SMILES

O=C1N(C2=CC=C(C=C2OC)OC)C3=NC(NC4=CC=C(C5CCN(CC5)C)C(OC)=C4)=NC=C3CN1C6=C(C)C=CC=C6C
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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YKL-05-093 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YKL-05-0932172616-44-1Salt-inducible Kinase (SIK)HDACRANKL/RANKHistone deacetylasesInhibitorinhibitorinhibit

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