2172616-44-1
Chemical Structure
YKL-05-093
- CAS No.: 2172616-44-1
- Formula:C35H40N6O4
- Molecular Weight:608.73
IUPAC Name: 1-(2,4-dimethoxyphenyl)-3-(2,6-dimethylphenyl)-7-((3-methoxy-4-(1-methylpiperidin-4-yl)phenyl)amino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one
InChIKey: BFXIHIYDDUBLGG-UHFFFAOYSA-N
SMILES: O=C1N(C2=CC=C(C=C2OC)OC)C3=NC(NC4=CC=C(C5CCN(CC5)C)C(OC)=C4)=NC=C3CN1C6=C(C)C=CC=C6C
Biological Activity: YKL-05-093 is a salt-induced kinase (SIK) inhibitor (SIK2: Kd = 7.1 nM). YKL-05-093 reduces the phosphorylation level of HDAC4/5/CRTC2, inhibits SOST expression, and stimulates RANKL expression in vitro and in vivo. YKL-05-093 can be used in research on bone diseases[1].
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YKL-05-093 | YKL-05-093 is a salt-induced kinase (SIK) inhibitor (SIK2: Kd = 7.1 nM). YKL-05-093 reduces the phosphorylation level of HDAC4/5/CRTC2, inhibits SOST expression, and stimulates RANKL expression in vitro and in vivo. YKL-05-093 can be used in research on bone diseases. | |||||||||||||||||||||
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