Gns - glucosamine (N-acetyl)-6-sulfatase Gene

Also Known as G6S; 2610016K11Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 75612

Summary

Predicted to enable N-acetylglucosamine-6-sulfatase activity; glycosaminoglycan binding activity; and sulfate binding activity. Predicted to be involved in keratan sulfate catabolic process. Located in lysosome. Is expressed in several structures, including eye; nervous system; skeleton; and spleen primordium. Used to study mucopolysaccharidosis III. Human ortholog(s) of this gene implicated in mucopolysaccharidosis III and mucopolysaccharidosis type IIID. Orthologous to human GNS (glucosamine (N-acetyl)-6-sulfatase). [provided by Alliance of Genome Resources, Apr 2022]

Gns Products (2)

mRNA Protein Name
NM_001364695.1 NP_001351624.1 N-acetylglucosamine-6-sulfatase isoform 2
NM_029364.4 NP_083640.1 N-acetylglucosamine-6-sulfatase isoform 1 precursor

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
located in lysosome IDA
IDA: Inferred from direct assay
29514215 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

N-acetylglucosamine-6-sulfatase

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-109061 Lazertinib 99.87% Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-137978A Ezurpimtrostat hydrochloride 99.26% Phase 2

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-109061B Lazertinib mesylate 99.85% Unkown
HY-137978 Ezurpimtrostat 99.37% Unkown
HY-109061A Lazertinib mesylate hydrate / Unkown
HY-183351 GN-604 / Unkown
HY-RS05581 GNS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19296 Gns Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25787 Gns Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gns NCBI NCBI:2799