Kndc1 - kinase non-catalytic C-lobe domain (KIND) containing 1 Gene

Also Known as VKIND; v-KIND; very-kind; 2410012C07Rik; B830014K08Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 76484

Summary

Enables guanyl-nucleotide exchange factor activity. Acts upstream of or within cerebellar granule cell differentiation; positive regulation of protein phosphorylation; and regulation of dendrite morphogenesis. Located in dendrite and neuronal cell body. Part of guanyl-nucleotide exchange factor complex. Is expressed in lung; nervous system; neural retina; ovary; and thymus. Orthologous to human KNDC1 (kinase non-catalytic C-lobe domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]

Kndc1 Products (1)

mRNA Protein Name
NM_177261.4 NP_796235.4 kinase non-catalytic C-lobe domain-containing protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
17984326 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17984326 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cerebellar granule cell differentiation IMP
IMP: Inferred from mutant phenotype
17984326 MGI
acts upstream of or within positive regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
17984326 MGI
acts upstream of or within regulation of dendrite development IDA
IDA: Inferred from direct assay
17984326 MGI
acts upstream of or within regulation of dendrite morphogenesis IDA
IDA: Inferred from direct assay
17984326 MGI
Cellular Component GO Annotation Evidence References Source
located in dendrite IDA
IDA: Inferred from direct assay
17984326 MGI
part of guanyl-nucleotide exchange factor complex IDA
IDA: Inferred from direct assay
17984326 MGI
located in neuronal cell body IDA
IDA: Inferred from direct assay
17984326 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

kinase non-catalytic C-lobe domain-containing protein 1

  • KIND domain-containing protein 1

  • protein very KIND

  • ras-GEF domain-containing family member 2

Kndc1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Kndc1 Q0KK55 Map2 Mus musculus P20357
Pull Down
21385318
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07410 KNDC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kndc1 NCBI NCBI:85442