TMEM163 - transmembrane protein 163 Gene

Also Known as DC29; SV31

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 81615

About TMEM163

Cytogenetic location: 2q21.3 Genomic coordinates (GRCh38): 2:134,455,759-134,719,000 (from NCBI)

This gene has 3 transcripts (splice variants) and 273 orthologues. Broad expression in lung (RPKM 2.2), brain (RPKM 1.9) and 15 other tissues.

Summary

Predicted to enable zinc ion binding activity. Predicted to be involved in zinc ion import into synaptic vesicle. Predicted to be located in early endosome membrane. Predicted to be active in intracellular vesicle and plasma membrane. Predicted to be integral component of synaptic vesicle membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMEM163 Products (1)

mRNA	Protein	Name
NM_030923.5	NP_112185.1	transmembrane protein 163

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25130899	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in myelination	IMP IMP: Inferred from mutant phenotype	35455965	GOA
involved in zinc export across plasma membrane	IDA IDA: Inferred from direct assay	31697912	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
transmembrane protein 163

TMEM163 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TMEM163	Q8TC26	SLC30A3	Homo sapiens	Q99726	Anti Tag CoIP	36204728
Intra	TMEM163	Q8TC26	SLC30A3	Homo sapiens	Q99726	Confocal	36204728
Intra	TMEM163	Q8TC26	SLC30A1	Homo sapiens	Q9Y6M5	Anti Tag CoIP	36204728
Intra	TMEM163	Q8TC26	SLC30A1	Homo sapiens	Q9Y6M5	Confocal	36204728
Intra	TMEM163	Q8TC26	SLC30A4	Homo sapiens	O14863	Anti Tag CoIP	36204728
Intra	TMEM163	Q8TC26	SLC30A4	Homo sapiens	O14863	Confocal	36204728
Intra	TMEM163	Q8TC26	SLC30A2	Homo sapiens	Q9BRI3	Confocal	36204728
Intra	TMEM163	Q8TC26	SLC30A2	Homo sapiens	Q9BRI3	Anti Tag CoIP	36204728

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Retinitis Pigmentosa 3	RP3 Retinitis Pigmentosa 15 Rp15 Choroidoretinal Degeneration With Retinal Reflex In Heterozygous Women Cone-Rod Degeneration, X-Linked Retinitis Pigmentosa Type 15 X-Linked Cone-Rod Degeneration X-Linked Retinitis Pigmentosa 3 Xlrp3 Xlrp-3 Retinitis Pigmentosa-3 Retinitis Pigmentosa, Type 3
Brachydactyly, Type A1	Brachydactyly Type A1 BDA1 Farabee-Type Brachydactyly Farabee Type Brachydactyly Brachydactyly Farabee Type Brachydactyly, Farabee Type Brachydactyly A1 Brachydactyly
Mucolipidosis Iv	Mucolipidosis Type Iv ML4 Sialolipidosis Mucolipidosis Type 4 Ganglioside Sialidase Deficiency Mliv Ml Iv Berman Syndrome Ganglioside Neuraminidase Deficiency Ml 4 Mucolipidosis 4 Type Iv Mucolipidosis Gangliosidoses

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14677	TMEM163 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TMEM163	VGNC	VGNC:35988
Felis catus	TMEM163	VGNC	VGNC:107679
Mus musculus	TMEM163	MGD	MGI:1919410
Canis familiaris	TMEM163	VGNC	VGNC:49815
Rattus norvegicus	TMEM163	RGD	RGD:1306212
Macaca mulatta	TMEM163	VGNC	VGNC:104557