Adcy2 - adenylate cyclase 2 Gene

Also Known as AC2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81636

Summary

Enables several functions, including G-protein beta/gamma-subunit complex binding activity; Adenylate Cyclase binding activity; and metal ion binding activity. Involved in several processes, including cAMP biosynthetic process; cAMP-mediated signaling; and cellular response to forskolin. Located in membrane raft and plasma membrane. Is integral component of plasma membrane. Part of protein-containing complex. Orthologous to human ADCY2 (Adenylate Cyclase 2). [provided by Alliance of Genome Resources, Apr 2022]

Adcy2 Products (1)

mRNA Protein Name
NM_031007.3 NP_112269.2 adenylate cyclase type 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G-protein beta/gamma-subunit complex binding IPI
IPI: Inferred from physical interaction
16967511 RGD
enables adenylate cyclase activity IDA
IDA: Inferred from direct assay
1719547 RGD
enables adenylate cyclase binding IDA
IDA: Inferred from direct assay
18164588 RGD
enables magnesium ion binding IDA
IDA: Inferred from direct assay
10427002 RGD
enables manganese ion binding IDA
IDA: Inferred from direct assay
10427002 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
18772391 RGD
Biological Process GO Annotation Evidence References Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
7761832 RGD
involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
18164588 RGD
involved in cAMP biosynthetic process IDA
IDA: Inferred from direct assay
10427002 RGD
involved in cAMP-mediated signaling IDA
IDA: Inferred from direct assay
7761832 RGD
involved in cellular response to forskolin IDA
IDA: Inferred from direct assay
1719547 RGD
Cellular Component GO Annotation Evidence References Source
located in membrane IDA
IDA: Inferred from direct assay
18164588 RGD
located in membrane raft IDA
IDA: Inferred from direct assay
18164588 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
7761832 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
16967511 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

adenylate cyclase type 2

  • ATP pyrophosphate-lyase 2

  • adenylate cyclase 2 (brain)

  • adenylate cyclase type II

  • adenylyl cyclase 2

Adcy2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Adcy2 P26769 AKAP9 Homo sapiens Q99996-4
Pull Down
18772391
Cross
Adcy2 P26769 PDE4D Homo sapiens Q08499-2
Anti Bait CoIP
20664520
Cross
Adcy2 P26769 PDE4D Homo sapiens Q08499-2
Anti Tag CoIP
20664520
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00328 ADCY2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21474 Adcy2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27992 Adcy2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adcy2 NCBI NCBI:108