ADCY2 - adenylate cyclase 2 Gene

Homo sapiens

Also known as AC2; HBAC2

Gene ID: 108 | Gene type: protein coding

About ADCY2

Cytogenetic location: 5p15.31 Genomic coordinates (GRCh38): 5:7,396,138-7,830,081 (from NCBI)

This gene has 8 transcripts (splice variants), 254 orthologues and 17 paralogues. Biased expression in brain (RPKM 19.2), prostate (RPKM 3.0) and 6 other tissues.

Summary

This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This Enzyme is insensitive to Ca(2+)/Calmodulin, and is stimulated by the G protein beta and gamma subunit complex. [provided by RefSeq, Jul 2008]

ADCY2 Products(1)

mRNA	Protein	Name
NM_020546.3	NP_065433.2	adenylate cyclase type 2

ADCY2 Protein Structure

Guanylate_cyc

DUF1053

Guanylate_cyc

0
200
400
600
800
1000
1091 a.a.

Protein Preferred Names

Protein Names

adenylate cyclase type 2

3',5'-cyclic AMP synthetase

Related Diseases

Diseases

Alias

Kleine-Levin Hibernation Syndrome

Kleine-Levin Syndrome	Familial Kleine-Levin Syndrome
Kleine Levin Syndrome	Familial Hibernation Syndrome
Recurrent Hypersomnolence	Hypersomnia-Bulimia Syndrome

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00328	ADCY2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ADCY2	VGNC	VGNC:59615
Mus musculus	ADCY2	MGD	MGI:99676
Macaca mulatta	ADCY2	VGNC	VGNC:69506
Rattus norvegicus	ADCY2	RGD	RGD:619965
Canis familiaris	ADCY2	VGNC	VGNC:37619
Bos taurus	ADCY2	VGNC	VGNC:25643

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