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ADCY2 - adenylate cyclase 2 Gene

Also Known as AC2; HBAC2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 108

About ADCY2

Cytogenetic location: 5p15.31 Genomic coordinates (GRCh38): 5:7,396,138-7,830,081 (from NCBI)

This gene has 8 transcripts (splice variants), 254 orthologues and 17 paralogues. Biased expression in brain (RPKM 19.2), prostate (RPKM 3.0) and 6 other tissues.

Summary

This gene encodes a member of the family of adenylate cyclases, which are membrane-associated Enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to CA(2+)/Calmodulin, and is stimulated by the G protein beta and gamma subunit complex. [provided by RefSeq, Jul 2008]

ADCY2 Products (1)

mRNA	Protein	Name
NM_020546.3	NP_065433.2	adenylate cyclase type 2

Gene Ontology

Cellular Component

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11549699	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	11549699	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADCY2 Protein Structure

Guanylate_cyc

DUF1053

Guanylate_cyc

0
200
400
600
800
1000
1091 a.a.

Protein Preferred Names	Protein Names
adenylate cyclase type 2	3',5'-cyclic AMP synthetase

Related Diseases

Diseases	Alias
Kleine-Levin Hibernation Syndrome	Kleine-Levin Syndrome Familial Kleine-Levin Syndrome Kleine Levin Syndrome Familial Hibernation Syndrome Recurrent Hypersomnolence Hypersomnia-Bulimia Syndrome
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00328	ADCY2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21474	Adcy2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27992	Adcy2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ADCY2	VGNC	VGNC:59615
Mus musculus	ADCY2	MGD	MGI:99676
Macaca mulatta	ADCY2	VGNC	VGNC:69506
Rattus norvegicus	ADCY2	RGD	RGD:619965
Canis familiaris	ADCY2	VGNC	VGNC:37619
Bos taurus	ADCY2	VGNC	VGNC:25643
Others	ADCY2	NCBI