Abcc6 - ATP binding cassette subfamily C member 6 Gene

Also Known as Mrp6

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81642

Summary

Enables several functions, including ATP binding activity; ATP hydrolysis activity; and inorganic diphosphate transmembrane transporter activity. Involved in anion transport; cellular phosphate ion homeostasis; and xenobiotic transmembrane transport. Located in apical plasma membrane; basolateral plasma membrane; and lateral plasma membrane. Used to study pseudoxanthoma elasticum. Human ortholog(s) of this gene implicated in arterial calcification of infancy; coronary artery disease; and pseudoxanthoma elasticum. Orthologous to human ABCC6 (ATP binding cassette subfamily C member 6). [provided by Alliance of Genome Resources, Apr 2022]

Abcc6 Products (1)

mRNA Protein Name
NM_031013.1 NP_112275.1 ATP-binding cassette sub-family C member 6

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ABC-type xenobiotic transporter activity IDA
IDA: Inferred from direct assay
10692506 RGD
enables ATP binding IDA
IDA: Inferred from direct assay
12069597 RGD
enables ATP hydrolysis activity IDA
IDA: Inferred from direct assay
12069597 RGD
enables inorganic diphosphate transmembrane transporter activity IDA
IDA: Inferred from direct assay
28111129 RGD
Biological Process GO Annotation Evidence References Source
involved in ATP transport IDA
IDA: Inferred from direct assay
33058196 RGD
involved in inorganic diphosphate transport IDA
IDA: Inferred from direct assay
28111129 RGD
involved in intracellular phosphate ion homeostasis IMP
IMP: Inferred from mutant phenotype
28111129 RGD
involved in xenobiotic transmembrane transport IDA
IDA: Inferred from direct assay
10692506 RGD
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
10692506 RGD
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
28111129 RGD
located in lateral plasma membrane IDA
IDA: Inferred from direct assay
10692506 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
33058196 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ATP-binding cassette sub-family C member 6

multidrug resistance-associated protein 6

  • ATP-binding cassette, sub-family C (CFTR/MRP), member 6

  • ATP-binding cassette, subfamily C (CFTR/MRP), member 6

  • MLP-1

  • MRP-like protein 1

  • liver multidrug resistance-associated protein 6

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-183032 ABC transporter modulator-1 Activator 96.30% Unkown
HY-183033 ABC transporter modulator-2 Activator 96.89% Unkown
HY-183034 ABC transporter modulator-3 Activator 97.0% Unkown
HY-183035 ABC transporter modulator-4 Modulator / Unkown
HY-183036 ABC transporter modulator-5 Modulator / Unkown
HY-RS00065 ABCC6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Abcc6 NCBI NCBI:368