PDPK1 - Pdpk1 3-phosphoinositide dependent protein kinase-1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81745

Summary

Enables 3-phosphoinositide-dependent protein kinase activity; Insulin Receptor binding activity; and protein kinase binding activity. Involved in cellular response to brain-derived neurotrophic factor stimulus; focal adhesion assembly; and negative regulation of neuron apoptotic process. Located in cytosol; perikaryon; and plasma membrane. Human ortholog(s) of this gene implicated in prostate Cancer. Orthologous to several human genes including PDPK1 (3-phosphoinositide dependent protein kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

PDPK1 Products (1)

mRNA Protein Name
NM_031081.2 NP_112343.2 3-phosphoinositide-dependent protein kinase 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 3-phosphoinositide-dependent protein kinase activity IDA
IDA: Inferred from direct assay
14585963 RGD
enables insulin receptor binding IDA
IDA: Inferred from direct assay
16314505 RGD
enables protein kinase binding IDA
IDA: Inferred from direct assay
14585963 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to brain-derived neurotrophic factor stimulus IEP
IEP: Inferred from expression pattern
18971483 RGD
involved in focal adhesion assembly IMP
IMP: Inferred from mutant phenotype
14585963 RGD
involved in negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
18971483 RGD
Cellular Component GO Annotation Evidence References Source
located in perikaryon IDA
IDA: Inferred from direct assay
18971483 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

3-phosphoinositide-dependent protein kinase 1

  • pkB kinase

  • protein kinase B kinase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12063 PHT-427 98.09% Unkown
HY-123467 Lasiokaurin 99.68% Unkown
HY-N1022 11-Hydroxytephrosin Inhibitor ≥98.0% Unkown
HY-108263B (R)-3-Hydroxy Midostaurin Inhibitor / Unkown
HY-RS10287 PDPK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W719359 PHT-427-d4 / Unkown
HY-N11231 Fucoxanthinol / Unkown
HY-RS17027 Pdpk1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23470 Pdpk1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens PDPK1 NCBI NCBI:5170