PDPK1 - 3-phosphoinositide dependent protein kinase 1 Gene

Also Known as PDK1; PDPK2; PDPK2P; PRO0461

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5170

About PDPK1

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:2,538,021-2,603,188 (from NCBI)

This gene has 17 transcripts (splice variants), 237 orthologues and 5 paralogues. Ubiquitous expression in brain (RPKM 5.6), testis (RPKM 5.3) and 25 other tissues.

Summary

Enables 3-phosphoinositide-dependent protein kinase activity; Phospholipase activator activity; and Phospholipase binding activity. Involved in several processes, including cell surface receptor signaling pathway; regulation of protein kinase activity; and regulation of signal transduction. Acts upstream of or within intracellular signal transduction. Located in cell projection; cytosol; and plasma membrane. Implicated in prostate Cancer. Biomarker of lung non-small cell carcinoma. [provided by Alliance of Genome Resources, Apr 2022]

PDPK1 Products (3)

mRNA	Protein	Name
NM_001261816.2	NP_001248745.1	3-phosphoinositide-dependent protein kinase 1 isoform 3
NM_002613.5	NP_002604.1	3-phosphoinositide-dependent protein kinase 1 isoform 1
NM_031268.6	NP_112558.2	3-phosphoinositide-dependent protein kinase 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 3-phosphoinositide-dependent protein kinase activity	IDA IDA: Inferred from direct assay	9368760	GOA
enables phospholipase activator activity	IMP IMP: Inferred from mutant phenotype	22454520	GOA
enables phospholipase binding	IPI IPI: Inferred from physical interaction	22454520	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11438723	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	9368760	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in activation of protein kinase B activity	IDA IDA: Inferred from direct assay	9368760	GOA
involved in calcium-mediated signaling	IMP IMP: Inferred from mutant phenotype	22454520	GOA
involved in cell migration	IMP IMP: Inferred from mutant phenotype	22454520	GOA
involved in cellular response to epidermal growth factor stimulus	IMP IMP: Inferred from mutant phenotype	22454520	GOA
involved in cellular response to insulin stimulus	IMP IMP: Inferred from mutant phenotype	10567711	GOA
involved in epidermal growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	22454520	GOA
involved in extrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	16207722	GOA
acts upstream of or within intracellular signal transduction	IDA IDA: Inferred from direct assay	14749367	GOA
involved in negative regulation of endothelial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	26235810	GOA
involved in negative regulation of protein kinase activity	IDA IDA: Inferred from direct assay	9373175	GOA
involved in negative regulation of transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	17327236	GOA
involved in peptidyl-threonine phosphorylation	IDA IDA: Inferred from direct assay	9368760	GOA
involved in positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	23802567	GOA
involved in positive regulation of blood vessel endothelial cell migration	IMP IMP: Inferred from mutant phenotype	23802567	GOA
involved in positive regulation of phospholipase activity	IMP IMP: Inferred from mutant phenotype	22454520	GOA
involved in positive regulation of protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	10567711	GOA
involved in positive regulation of release of sequestered calcium ion into cytosol	IDA IDA: Inferred from direct assay	22454520	GOA
involved in positive regulation of sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	26235810	GOA
involved in positive regulation of vascular endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	23802567	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	14585963	GOA
involved in regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	16207722	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell projection	IDA IDA: Inferred from direct assay	22454520	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	9637919	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	9637919	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDPK1 Protein Structure

Pkinase

PH_3

0
100
200
300
400
500
556 a.a.

Protein Preferred Names	Protein Names
3-phosphoinositide-dependent protein kinase 1	3-phosphoinositide-dependent protein kinase 2 pseudogene

PDPK1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PDPK1	O15530	PPP2R2B	Homo sapiens	Q00005	Anti Bait CoIP	21075311
Intra	PDPK1	O15530	PPP2R2B	Homo sapiens	Q00005	Anti Tag CoIP	21075311
Intra	PDPK1	O15530	TBL2	Homo sapiens	Q9Y4P3	Anti Tag CoIP	33961781
Intra	PDPK1	O15530	TBL2	Homo sapiens	Q9Y4P3	Anti Tag CoIP	20562859
Intra	PDPK1	O15530	AKT1	Homo sapiens	P31749	Protein Kinase Assay	26256536
Intra	PDPK1	O15530	AKT1	Homo sapiens	P31749	Anti Bait CoIP	21775285
Intra	PDPK1	O15530	AKT1	Homo sapiens	P31749	Beta Lactamase	11438723
Intra	PDPK1	O15530	ULK1	Homo sapiens	O75385	CoIP	26593251

Cross: Cross-species interaction Intra: Intraspecies interaction

PDPK1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81824	PDPK1 Antibody (YA1569)	WB	Human, Mouse, Rat
HY-P81824A	PDPK1 Antibody (YA1569)(PBS only)	WB	Human, Mouse, Rat
HY-P86089	Phospho-PDPK1(Ser241) Antibody (YA5781)	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
HY-P86174	PDPK1 Antibody (YA5866)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Cowden Syndrome 6	CWS6 Cowden Syndrome, Type 6
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Intestinal Obstruction	Inspissated Milk Syndrome Milk Curd Syndrome
Small Cell Carcinoma	Small Cell Carcinoma, Intermediate Cell Intermediate Cell Small Cell Carcinoma Small Cell Carcinoma - Intermediate Cell Small Cell Carcinoma Of Lung Carcinoma, Small Cell
Esophageal Adenosquamous Carcinoma
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12063	PHT-427		98.09%	Unkown
HY-123467	Lasiokaurin		99.68%	Unkown
HY-N1022	11-Hydroxytephrosin	Inhibitor	≥98.0%	Unkown
HY-108263B	(R)-3-Hydroxy Midostaurin	Inhibitor	/	Unkown
HY-RS10287	PDPK1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W719359	PHT-427-d4		/	Unkown
HY-RS17027	Pdpk1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23470	Pdpk1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PDPK1	MGD	MGI:1338068
Canis familiaris	PDPK1	VGNC	VGNC:54055
Rattus norvegicus	PDPK1	RGD	RGD:620307
Felis catus	PDPK1	VGNC	VGNC:107808
Others	PDPK1	NCBI