Sorcs2 - sortilin-related VPS10 domain containing receptor 2 Gene

Mus musculus

Also known as mKIAA1329

Gene ID: 81840 | Gene type: protein coding

About Sorcs2

Summary

Involved in intracellular protein transport and long-term synaptic depression. Located in early endosome membrane; postsynaptic density; and recycling endosome membrane. Is integral component of plasma membrane. Is expressed in several structures, including brain; future spinal cord; musculature; sensory organ; and spinal cord. Orthologous to human SORCS2 (sortilin related VPS10 domain containing receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Sorcs2 Products(1)

mRNA	Protein	Name
NM_030889.2	NP_112151.2	VPS10 domain-containing receptor SorCS2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24908487	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in intracellular protein transport	IMP IMP: Inferred from mutant phenotype	30840898	MGI
involved in long-term synaptic depression	IMP IMP: Inferred from mutant phenotype	27457814	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in early endosome membrane	IDA IDA: Inferred from direct assay	30840898	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	30840898	MGI
located in postsynaptic density	IDA IDA: Inferred from direct assay	27457814	MGI
located in recycling endosome membrane	IDA IDA: Inferred from direct assay	30840898	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

VPS10 domain-containing receptor SorCS2

VPS10 domain receptor protein SORCS 2

Sorcs2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Sorcs2	Q9EPR5	Ngfr	Mus musculus	Q9Z0W1	Confocal	24908487

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13571	SORCS2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sorcs2	NCBI	NCBI:57537

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