Sorcs2 - sortilin-related VPS10 domain containing receptor 2 Gene

Also Known as mKIAA1329

Species: Mus musculus

Gene Type: protein coding
Gene ID: 81840

Summary

Involved in intracellular protein transport and long-term synaptic depression. Located in early endosome membrane; postsynaptic density; and recycling endosome membrane. Is integral component of plasma membrane. Is expressed in several structures, including brain; future spinal cord; musculature; sensory organ; and spinal cord. Orthologous to human SORCS2 (sortilin related VPS10 domain containing receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Sorcs2 Products (1)

mRNA Protein Name
NM_030889.2 NP_112151.2 VPS10 domain-containing receptor SorCS2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
24908487 MGI
Biological Process GO Annotation Evidence References Source
involved in intracellular protein transport IMP
IMP: Inferred from mutant phenotype
30840898 MGI
involved in long-term synaptic depression IMP
IMP: Inferred from mutant phenotype
27457814 MGI
Cellular Component GO Annotation Evidence References Source
located in early endosome membrane IDA
IDA: Inferred from direct assay
30840898 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
30840898 MGI
located in postsynaptic density IDA
IDA: Inferred from direct assay
27457814 MGI
located in recycling endosome membrane IDA
IDA: Inferred from direct assay
30840898 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

VPS10 domain-containing receptor SorCS2

  • VPS10 domain receptor protein SORCS 2

Sorcs2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Sorcs2 Q9EPR5 Ngfr Mus musculus Q9Z0W1
Confocal
24908487
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13571 SORCS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sorcs2 NCBI NCBI:57537