Siglece - sialic acid binding Ig-like lectin E Gene

Mus musculus

Also known as Cd170; Siglec5; Siglec9; Siglec12; Siglecl1; mSiglec-E

Gene ID: 83382 | Gene type: protein coding

About Siglece

Summary

Enables monosaccharide binding activity and sialic acid binding activity. Acts upstream of or within cell adhesion; negative regulation of inflammatory response; and negative regulation of phagocytosis, engulfment. Located in external side of plasma membrane. Is expressed in several structures, including gonad; heart; hemolymphoid system gland; liver; and lung. Orthologous to several human genes including SIGLEC8 (sialic acid binding Ig like lectin 8). [provided by Alliance of Genome Resources, Apr 2022]

Siglece Products(1)

mRNA	Protein	Name
NM_031181.2	NP_112458.2	sialic acid-binding Ig-like lectin 12 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables monosaccharide binding	IDA IDA: Inferred from direct assay	15048729	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11171044	MGI
enables sialic acid binding	IDA IDA: Inferred from direct assay	11171044	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cell adhesion	IDA IDA: Inferred from direct assay	11171044	MGI
acts upstream of inflammatory response	IMP IMP: Inferred from mutant phenotype	24227736	MGI
acts upstream of or within negative regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	24227736	MGI
acts upstream of or within negative regulation of phagocytosis, engulfment	IDA IDA: Inferred from direct assay	24227736	MGI
acts upstream of or within negative regulation of phagocytosis, engulfment	IMP IMP: Inferred from mutant phenotype	24227736	MGI
acts upstream of phagocytosis, engulfment	IMP IMP: Inferred from mutant phenotype	24227736	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	24227736	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

sialic acid-binding Ig-like lectin 12

MIS	SIGLEC-like 1
myeloid inhibitory siglec	sialic acid binding Ig-like lectin 5
sialic acid-binding Ig-like lectin-like 1	sialic acid-binding immunoglobulin-like lectin E
siglec-12	siglec-5
siglec-E	siglec-L1

Siglece Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Siglec12	Q91Y57	Tlr4	Mus musculus	Q9QUK6	Anti Bait CoIP	25187624
Intra	Siglec12	Q91Y57	Tlr4	Mus musculus	Q9QUK6	Affinity Chrom	25187624

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-E70302	ST8 alpha-2,8-Sialyltransferase 6		/	Unkown

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