Siglece - sialic acid binding Ig-like lectin E Gene

Also Known as Cd170; Siglec5; Siglec9; Siglec12; Siglecl1; mSiglec-E

Species: Mus musculus

Gene Type: protein coding
Gene ID: 83382

Summary

Enables monosaccharide binding activity and sialic acid binding activity. Acts upstream of or within cell adhesion; negative regulation of inflammatory response; and negative regulation of phagocytosis, engulfment. Located in external side of plasma membrane. Is expressed in several structures, including gonad; heart; hemolymphoid system gland; liver; and lung. Orthologous to several human genes including SIGLEC8 (sialic acid binding Ig like lectin 8). [provided by Alliance of Genome Resources, Apr 2022]

Siglece Products (1)

mRNA Protein Name
NM_031181.2 NP_112458.2 sialic acid-binding Ig-like lectin 12 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables monosaccharide binding IDA
IDA: Inferred from direct assay
15048729 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11171044 MGI
enables sialic acid binding IDA
IDA: Inferred from direct assay
11171044 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell adhesion IDA
IDA: Inferred from direct assay
11171044 MGI
acts upstream of inflammatory response IMP
IMP: Inferred from mutant phenotype
24227736 MGI
acts upstream of or within negative regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
24227736 MGI
acts upstream of or within negative regulation of phagocytosis, engulfment IDA
IDA: Inferred from direct assay
24227736 MGI
acts upstream of or within negative regulation of phagocytosis, engulfment IMP
IMP: Inferred from mutant phenotype
24227736 MGI
acts upstream of phagocytosis, engulfment IMP
IMP: Inferred from mutant phenotype
24227736 MGI
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
24227736 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sialic acid-binding Ig-like lectin 12

  • MIS

  • SIGLEC-like 1

  • myeloid inhibitory siglec

  • sialic acid binding Ig-like lectin 5

  • sialic acid-binding Ig-like lectin-like 1

  • sialic acid-binding immunoglobulin-like lectin E

  • siglec-12

  • siglec-5

  • siglec-E

  • siglec-L1

Siglece Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Siglec12 Q91Y57 Tlr4 Mus musculus Q9QUK6
Anti Bait CoIP
25187624
Intra
Siglec12 Q91Y57 Tlr4 Mus musculus Q9QUK6
Affinity Chrom
25187624
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-E70302 ST8 alpha-2,8-Sialyltransferase 6 / Unkown