1. Gene
  2. Tlr4 - toll-like receptor 4 Gene

Tlr4 - toll-like receptor 4 Gene

Mus musculus

Also known as Lps; Ly87; Ran/M1; Rasl2-8

Gene ID: 21898 | Gene type: protein coding

About Tlr4

Chromosome 4: 66,745,821-66,848,521 forward strand.GRCm39:CM000997.3

This gene has 4 transcripts (splice variants), 127 orthologues, 23 paralogues and is associated with 133 phenotypes. Broad expression in bladder adult (RPKM 2.), subcutaneous fat pad adult (RPKM 1.2) and 2 other tissues.

Summary

This gene belongs to the evolutionarily-conserved Toll-like Receptor family, whose members are type-1 transmembrane proteins that are involved in innate immunity. Toll-like receptors are characterized by an extracellular leucine-rich repeat domain that functions in ligand recognition and an intracellular toll/interleukin-1 receptor-like domain that is crucial for signal transduction. The receptor encoded by this gene mediates the innate immune response to Bacterial lipopolysaccharide, a major component of the outer membrane of Gram-negative bacteria, through synthesis of pro-inflammatory cytokines and chemokines. In addition, this protein can recognize other pathogens from Gram-negative and Gram-positive bacteria as well as viral components. Mice deficient in this gene display a number of immune response-related phenotypes including hyporesponsiveness to Bacterial lipopolysaccharide and increased levels of respiratory syncytial virus compared to controls. [provided by RefSeq, Sep 2015]

Tlr4 Products(1)

mRNA Protein Name
NM_021297.3 NP_067272.1 toll-like receptor 4 precursor

Tlr4 Protein Structure

PLN00113

PLN00113: cl33413 (45 - 455)

LRR_RI

LRR_RI: sd00033 (57 - 77)

LRR_RI

LRR_RI: sd00033 (78 - 101)

LRR_RI

LRR_RI: sd00033 (102 - 125)

LRR_RI

LRR_RI: sd00033 (126 - 149)

LRR_RI

LRR_RI: sd00033 (150 - 174)

LRR_RI

LRR_RI: sd00033 (175 - 203)

LRR_RI

LRR_RI: sd00033 (204 - 225)

LRR_RI

LRR_RI: sd00033 (330 - 349)

LRR_RI

LRR_RI: sd00033 (350 - 371)

PPP1R42

PPP1R42: cl42388 (368 - 554)

LRR_RI

LRR_RI: sd00033 (372 - 397)

LRR_RI

LRR_RI: sd00033 (398 - 420)

LRR_RI

LRR_RI: sd00033 (421 - 445)

LRR_RI

LRR_RI: sd00033 (446 - 469)

LRR_RI

LRR_RI: sd00033 (470 - 494)

LRR_RI

LRR_RI: sd00033 (495 - 518)

LRR_RI

LRR_RI: sd00033 (519 - 542)

TIR

TIR: smart00255 (671 - 812)

  • 0
  • 200
  • 400
  • 600
  • 835 a.a.
Protein Preferred Names Protein Names

toll-like receptor 4

Toll like receptor 4

lipopolysaccharide response

Orthologs Information

Species Symbol Source ID
Homo sapiens Tlr4 NCBI NCBI:7099