Immethridine dihydrobromide

Name: Immethridine dihydrobromide
Brand: MedChemExpress
SKU: HY-108058A
Rating: 4.5 (1 reviews)

Cat. No.: HY-108058A Purity: 99.61%: Data Sheet
COA

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Handling Instructions
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Immethridine (dihydrobromide) is a potent and highly selective histamine H₃ receptor agonist with pK_i and pEC₅₀ value of 9.07 and 9.74, respectively. Immethridine can be used for the research of myocardial ischemia, inflammatory, and gastric acid related diseases research.

For research use only. We do not sell to patients.

Immethridine dihydrobromide Chemical Structure

CAS No. : 699020-93-4

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	Get quote
50 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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H₁ Receptor H₂ Receptor H₃ Receptor H₄ Receptor Histamine Receptor

Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

pKi: 9.07, pEC50: 9.74 (histamine H(3) receptor)^[1]

Molecular Weight

321.01

Formula

C₉H₁₁Br₂N₃

CAS No.

699020-93-4

Appearance

Solid

Color

Off-white to light yellow

SMILES

[H]Br.[H]Br.C1(CC2=CN=CN2)=CC=NC=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 15 mg/mL (46.73 mM; Need ultrasonic and warming)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1152 mL	15.5758 mL	31.1517 mL
5 mM	0.6230 mL	3.1152 mL	6.2303 mL
10 mM	0.3115 mL	1.5576 mL	3.1152 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Working solution concentration: mg/mL

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.61%

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Data Sheet (275 KB) SDS (252 KB)

COA (252 KB) LCMS (159 KB)

Handling Instructions (2659 KB)

References

[1]. Shi Y, et al. Immethridine, histamine H3-receptor (H3R) agonist, alleviated experimental autoimmune encephalomyelitis via inhibiting the function of dendritic cells. Oncotarget. 2017 Aug 24;8(43):75038-75049. [Content Brief]

[2]. Kitbunnadaj R, et al. Identification of 4-(1H-imidazol-4(5)-ylmethyl)pyridine (immethridine) as a novel, potent, and highly selective histamine H(3) receptor agonist. J Med Chem. 2004 May 6;47(10):2414-7.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	3.1152 mL	15.5758 mL	31.1517 mL	77.8792 mL
	5 mM	0.6230 mL	3.1152 mL	6.2303 mL	15.5758 mL
	10 mM	0.3115 mL	1.5576 mL	3.1152 mL	7.7879 mL
	15 mM	0.2077 mL	1.0384 mL	2.0768 mL	5.1919 mL
	20 mM	0.1558 mL	0.7788 mL	1.5576 mL	3.8940 mL
	25 mM	0.1246 mL	0.6230 mL	1.2461 mL	3.1152 mL
	30 mM	0.1038 mL	0.5192 mL	1.0384 mL	2.5960 mL
	40 mM	0.0779 mL	0.3894 mL	0.7788 mL	1.9470 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.