Antimicrobial Peptide YD
Antimicrobial Peptide YD is an Antimicrobial peptide. Antimicrobial Peptide YD attenuates the TLR4/MYD88/NF-κB signaling pathway, inhibits ROS production, upregulates the expression of antioxidant enzymes, reduces the levels of inflammation-related factors, and prevents the downregulation of E-cadherin and upregulation of Vimentin. Antimicrobial Peptide YD exhibits activity against Gram-positive bacteria, Gram-negative bacteria, and multidrug-resistant bacteria. Antimicrobial Peptide YD possesses anti-inflammatory, antifibrotic, and antioxidant effects. Antimicrobial Peptide YD can be used in pulmonary fibrosis research.
For research use only. We do not sell to patients.
- CAS No.: 2124174-65-6
- Formula: C39H65N13O13
- Molecular Weight:924.01
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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TLR4 |
Antimicrobial Peptide YD (50-100 μM) exhibits potent anti-inflammatory activity in lung epithelial A549 cells, and inhibits inflammation induced by the cytokine (TNFα) and oxidative stress (H2O2)[1].
Antimicrobial Peptide YD (25-50 μM; 24 h) inhibits the TGF-β1-induced fibrotic response in mouse fibroblast cell line NIH-3T3, and reduces the expression of key fibrotic proteins (α-SMA, MMP2, Col1, FN) and their corresponding mRNAs[1].
Antimicrobial Peptide YD inhibits TGF-β1-induced fibrotic responses and epithelial-mesenchymal transition in pulmonary epithelial A549 cells, reduces the expression of fibrosis markers, and maintains the epithelial cell phenotype[1].
Antimicrobial Peptide YD exhibits poor serum stability in mouse serum, with a half-life of 21.31 min[1].
Antimicrobial Peptide YD (24 h) inhibits TGF-β1-induced type I collagen expression in mouse fibroblast cell line NIH-3T3[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:mouse fibroblast NIH-3T3 cells
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Concentration:25 μM, 50 μM
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Incubation Time:24 h
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Result:Markedly inhibited TGF-β1-induced upregulation of the fibrotic proteins α-smooth muscle actin (α-SMA), matrix metalloproteinase-2 (MMP2), collagen I (Col1), and fibronectin (FN).
| Species | Dose | Route | AUC0-∞ | Plasma Concentration |
|---|---|---|---|---|
| Mice[1] | 2.5 mg/kg | i.v. | ~0.0007 μg·h/mL | 0.003 μg/mL |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 mice[1]
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Dosage:0.2 mg/kg; 0.5 mg/kg; 1.6 mg/kg
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Administration:i.p.; daily; 21 days
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Result:Significantly normalized protein and mRNA levels of fibrotic and epithelial-mesenchymal transition (EMT) markers (α-SMA, collagen I, fibronectin, Acta2, Col1a1, Fnl) in fibrotic lungs.
Reduced inflammatory cell infiltration, myofibroblast activation, and extracellular matrix (ECM) deposition in BLM-treated mouse lungs.
Reduced NOX4 protein and mRNA levels in lung tissues.
Promoted mRNA expression of antioxidant enzymes (Cat and Sod1).
Chemical Information
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CAS No. 2124174-65-6
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Molecular Weight 924.01
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Formula C39H65N13O13
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Sequence
Ala-Pro-Lys-Gly-Val-Gln-Gly-Pro-Asn-Gly
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Sequence Shortening
APKGVQGPNG
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antimicrobial Peptide YD Related Classifications
HY-P11913 Related Classifications
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- Antimicrobial Peptide YD
- 2124174-65-6
- Bacterial
- Toll-like Receptor (TLR)
- MyD88
- NF-κB
- Reactive Oxygen Species (ROS)
- Cadherin
- mouse fibroblast NIH-3T3 cells
- reactive oxygen species
- fibroblasts
- E-cadherin
- antioxidant enzymes
- vimentin
- Nrf2 pathway
- human lung epithelial A549 cells
- TGF-β1
- TLR4/MYD88/NF-κB signaling
- Inhibitor
- inhibitor
- inhibit