country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-P11913

Copy Link Print Information

Antimicrobial Peptide YD

Antimicrobial Peptide YD is an Antimicrobial peptide. Antimicrobial Peptide YD attenuates the TLR4/MYD88/NF-κB signaling pathway, inhibits ROS production, upregulates the expression of antioxidant enzymes, reduces the levels of inflammation-related factors, and prevents the downregulation of E-cadherin and upregulation of Vimentin. Antimicrobial Peptide YD exhibits activity against Gram-positive bacteria, Gram-negative bacteria, and multidrug-resistant bacteria. Antimicrobial Peptide YD possesses anti-inflammatory, antifibrotic, and antioxidant effects. Antimicrobial Peptide YD can be used in pulmonary fibrosis research.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 2124174-65-6
Formel: C₃₉H₆₅N₁₃O₁₃
Molecular Weight:924.01

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Kundenspezifische Peptidsynthese

Antimicrobial Peptide YD Chemical Structure

CAS. Nr.: 2124174-65-6

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

TLR4

Alle Toll-like Receptor (TLR) Isoform-spezifische Produkte anzeigen :

Alle NF-κB Isoform-spezifische Produkte anzeigen :

In Vitro

Antimicrobial Peptide YD (50-100 μM) exhibits potent anti-inflammatory activity in lung epithelial A549 cells, and inhibits inflammation induced by the cytokine (TNFα) and oxidative stress (H₂O₂)^[1].
Antimicrobial Peptide YD (25-50 μM; 24 h) inhibits the TGF-β1-induced fibrotic response in mouse fibroblast cell line NIH-3T3, and reduces the expression of key fibrotic proteins (α-SMA, MMP2, Col1, FN) and their corresponding mRNAs^[1].
Antimicrobial Peptide YD inhibits TGF-β1-induced fibrotic responses and epithelial-mesenchymal transition in pulmonary epithelial A549 cells, reduces the expression of fibrosis markers, and maintains the epithelial cell phenotype^[1].
Antimicrobial Peptide YD exhibits poor serum stability in mouse serum, with a half-life of 21.31 min^[1].
Antimicrobial Peptide YD (24 h) inhibits TGF-β1-induced type I collagen expression in mouse fibroblast cell line NIH-3T3^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

mouse fibroblast NIH-3T3 cells
Concentration:

25 μM, 50 μM
Incubation Time:

24 h
Result:

Markedly inhibited TGF-β1-induced upregulation of the fibrotic proteins α-smooth muscle actin (α-SMA), matrix metalloproteinase-2 (MMP2), collagen I (Col1), and fibronectin (FN).

Parmacokinetics

Species	Dose	Route	AUC_0-∞	Plasma Concentration
Mice^[1]	2.5 mg/kg	i.v.	~0.0007 μg·h/mL	0.003 μg/mL

In Vivo

Antimicrobial Peptide YD (0.2-1.6 mg/kg; i.p.; daily; for 21 consecutive days) exhibits potent anti-pulmonary fibrosis activity in a bleomycin (HY-108345)-induced mouse model. At an i.p. dose of 0.2 mg/kg, which results in significantly lower systemic exposure levels, its efficacy is comparable to that of the positive control agent Pirfenidone (HY-B0673)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6 mice^[1]
Dosage:

0.2 mg/kg; 0.5 mg/kg; 1.6 mg/kg
Administration:

i.p.; daily; 21 days
Result:

Significantly normalized protein and mRNA levels of fibrotic and epithelial-mesenchymal transition (EMT) markers (α-SMA, collagen I, fibronectin, Acta2, Col1a1, Fnl) in fibrotic lungs.
Reduced inflammatory cell infiltration, myofibroblast activation, and extracellular matrix (ECM) deposition in BLM-treated mouse lungs.
Reduced NOX4 protein and mRNA levels in lung tissues.
Promoted mRNA expression of antioxidant enzymes (Cat and Sod1).

Chemical Information

CAS. Nr. 2124174-65-6
Molecular Weight 924.01
Formel C₃₉H₆₅N₁₃O₁₃
Sequence

Ala-Pro-Lys-Gly-Val-Gln-Gly-Pro-Asn-Gly
Sequence Shortening

APKGVQGPNG
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Zhang J, et al. Cyclization-Based Optimization of the Antimicrobial Peptide YD Yields a Nanomolar Inhibitor of Pulmonary Fibrosis. Journal of medicinal chemistry. 2026 Mar 26;69(6):7443-7458.

[2]. Yan Z, et al. The antimicrobial peptide YD attenuates inflammation via miR-155 targeting CASP12 during liver fibrosis. Acta Pharm Sin B. 2021 Jan;11(1):100-111.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

Angebot einholen Auf Lager

Other size

Angebot einholen

Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

Antimicrobial Peptide YD

Alle Toll-like Receptor (TLR) Isoform-spezifische Produkte anzeigen

Alle NF-κB Isoform-spezifische Produkte anzeigen