2124174-65-6
Chemical Structure
Antimicrobial Peptide YD
- CAS No.: 2124174-65-6
- Formula:C39H65N13O13
- Molecular Weight:924.01
InChIKey: SFRIIGSSHFWQLW-VZUCPUBKSA-N
SMILES: O=C(N1[C@@H](CCC1)C(N[C@@H](CCCCN)C(NCC(N[C@@H](C(C)C)C(N[C@@H](CCC(N)=O)C(NCC(N2[C@@H](CCC2)C(N[C@@H](CC(N)=O)C(NCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C)N
Biological Activity: Antimicrobial Peptide YD is an Antimicrobial peptide. Antimicrobial Peptide YD attenuates the TLR4/MYD88/NF-κB signaling pathway, inhibits ROS production, upregulates the expression of antioxidant enzymes, reduces the levels of inflammation-related factors, and prevents the downregulation of E-cadherin and upregulation of Vimentin. Antimicrobial Peptide YD exhibits activity against Gram-positive bacteria, Gram-negative bacteria, and multidrug-resistant bacteria. Antimicrobial Peptide YD possesses anti-inflammatory, antifibrotic, and antioxidant effects. Antimicrobial Peptide YD can be used in pulmonary fibrosis research[1][2].
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Antimicrobial Peptide YD | Antimicrobial Peptide YD is an Antimicrobial peptide. Antimicrobial Peptide YD attenuates the TLR4/MYD88/NF-κB signaling pathway, inhibits ROS production, upregulates the expression of antioxidant enzymes, reduces the levels of inflammation-related factors, and prevents the downregulation of E-cadherin and upregulation of Vimentin. Antimicrobial Peptide YD exhibits activity against Gram-positive bacteria, Gram-negative bacteria, and multidrug-resistant bacteria. Antimicrobial Peptide YD possesses anti-inflammatory, antifibrotic, and antioxidant effects. Antimicrobial Peptide YD can be used in pulmonary fibrosis research. | |||||||||||||||||||||
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- [1]. Zhang J, et al. Cyclization-Based Optimization of the Antimicrobial Peptide YD Yields a Nanomolar Inhibitor of Pulmonary Fibrosis. Journal of medicinal chemistry. 2026 Mar 26;69(6):7443-7458.
- [2]. Yan Z, et al. The antimicrobial peptide YD attenuates inflammation via miR-155 targeting CASP12 during liver fibrosis. Acta Pharm Sin B. 2021 Jan;11(1):100-111.
Keywords
