Liriodendrin

Cat. No.: HY-N3377: Data Sheet Handling Instructions
FAQs
Technical Support

Liriodendrin is an HSF1 agonist can be isolated from E. ulmoides.

For research use only. We do not sell to patients.

Liriodendrin Chemical Structure

CAS No. : 573-44-4

Size	Price	Stock
1 mg		Ask For Quote & Lead Time
5 mg		Ask For Quote & Lead Time

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

1 Publications Citing Use of MCE Liriodendrin

•Int J Mol Med. 2025 Apr;55(4):65. [Abstract]

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All HSP Isoform Specific Products:

View All Isoforms

HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

Biological Activity
Purity & Documentation
References
Customer Review

Description

Liriodendrin is an HSF1 agonist can be isolated from E. ulmoides^[1].

IC₅₀ & Target

HSF1^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
BV-2	IC₅₀	>100 μM Compound: 21	Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs in presence of LPS by Griess reaction based assay Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs in presence of LPS by Griess reaction based assay	[PMID: 28911817]
Cancer cell lines	ED₅₀	16 μg/mL Compound: 6	Cytotoxicity against human colon cancer cells Cytotoxicity against human colon cancer cells	[PMID: 1965200]
Cancer cell lines	ED₅₀	30 μg/mL Compound: 6	Cytotoxicity against human breast cancer cells Cytotoxicity against human breast cancer cells	[PMID: 1965200]
Cancer cell lines	ED₅₀	6 μg/mL Compound: 6	Cytotoxicity against human lung cancer cells Cytotoxicity against human lung cancer cells	[PMID: 1965200]
HT-1080	ED₅₀	8.9 μg/mL Compound: 6	Cytotoxicity against human HT1080 cells Cytotoxicity against human HT1080 cells	[PMID: 1965200]
KB	ED₅₀	6 μg/mL Compound: 6	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 1965200]
Melanoma cell	ED₅₀	19 μg/mL Compound: 6	Cytotoxicity against human melanoma cells Cytotoxicity against human melanoma cells	[PMID: 1965200]
N9	IC₅₀	>100 μM Compound: 19	Antineuroinflammatory activity in mouse N9 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay Antineuroinflammatory activity in mouse N9 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay	[PMID: 28073678]
P388	ED₅₀	2.4 μg/mL Compound: 6	Cytotoxicity against mouse P388 cells Cytotoxicity against mouse P388 cells	[PMID: 1965200]
RAW264.7	IC₅₀	0.112 mM Compound: 24	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs	[PMID: 18986199]
RAW264.7	IC₅₀	0.112 μM/mL Compound: 24	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs	[PMID: 18986199]

Molecular Weight

742.72

Formula

C₃₄H₄₆O₁₈

CAS No.

573-44-4

SMILES

COC1=C(O[C@@H]2O[C@@H]([C@H]([C@@H]([C@H]2O)O)O)CO)C(OC)=CC([C@@H]3[C@]4([H])[C@@](CO3)([H])[C@@H](C5=CC(OC)=C(C(OC)=C5)O[C@@H]6O[C@@H]([C@H]([C@@H]([C@H]6O)O)O)CO)OC4)=C1

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Nam JW, et al. Heat shock factor 1 inducers from the bark of Eucommia ulmoides as cytoprotective agents. Chem Biodivers. 2013 Jul;10(7):1322-7. [Content Brief]

Liriodendrin Related Classifications

Others

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Liriodendrin573-44-4HSPHeat shock proteinsHSF1 AgonistInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Requested Quantity *

Applicant Name *

Salutation

Email Address *

Phone Number *

Department

Organization Name *

City

State

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *