573-44-4
Chemical Structure
Liriodendrin
- CAS No.: 573-44-4
- Formula:C34H46O18
- Molecular Weight:742.72
IUPAC Name: (2R,2'R,3S,3'S,4S,4'S,5R,5'R,6S,6'S)-6,6'-((((1S,3aR,4S,6aR)-tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl)bis(2,6-dimethoxy-4,1-phenylene))bis(oxy))bis(2-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol)
InChIKey: FFDULTAFAQRACT-XKBSQSBASA-N
SMILES: COC1=C(O[C@@H]2O[C@@H]([C@H]([C@@H]([C@H]2O)O)O)CO)C(OC)=CC([C@@H]3[C@]4([H])[C@@](CO3)([H])[C@@H](C5=CC(OC)=C(C(OC)=C5)O[C@@H]6O[C@@H]([C@H]([C@@H]([C@H]6O)O)O)CO)OC4)=C1
Biological Activity: Liriodendrin is an orally effective lignan compound with anti-inflammatory, antioxidant, and anti-platelet aggregation activities. Liriodendrin is isolated and extracted from Sargentodoxae caulis and Linaria vulgaris. Liriodendrin regulates the expression of genes related to inflammation and cellular metabolism by inhibiting the NF-κB, PI3K/Akt, and TLR4 signaling pathways, or by activating the PI3K-DDX18 pathway. Liriodendrin increases the expression of HSF1 and HSP27 without cytotoxicity. Liriodendrin is used in studies on ulcerative colitis, myocardial ischemia-reperfusion injury, sepsis-induced acute lung injury, and chronic endometritis[1][2][3][4][5][6].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Liriodendrin | 99.02% | Liriodendrin is an orally effective lignan compound with anti-inflammatory, antioxidant, and anti-platelet aggregation activities. Liriodendrin is isolated and extracted from Sargentodoxae caulis and Linaria vulgaris. Liriodendrin regulates the expression of genes related to inflammation and cellular metabolism by inhibiting the NF-κB, PI3K/Akt, and TLR4 signaling pathways, or by activating the PI3K-DDX18 pathway. Liriodendrin increases the expression of HSF1 and HSP27 without cytotoxicity. Liriodendrin is used in studies on ulcerative colitis, myocardial ischemia-reperfusion injury, sepsis-induced acute lung injury, and chronic endometritis. | ||||||||||||||||||||
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References
- [1]. Nam JW, et al. Heat shock factor 1 inducers from the bark of Eucommia ulmoides as cytoprotective agents. Chemistry & biodiversity. 2013 Jul;10(7):1322-7. [Content Brief]
- [2]. Cheng F, et al. Liriodendrin exerts protective effects against chronic endometritis in rats by modulating gut microbiota composition and the arginine/nitric oxide metabolic pathway. International immunopharmacology. 2024 Jan 05;126:111235.
- [3]. Li B, et al. Liriodendrin alleviates myocardial ischemia‑reperfusion injury via partially attenuating apoptosis, inflammation and mitochondria damage in rats. International journal of molecular medicine. 2025 Apr;55(4):65. [Content Brief]
- [4]. Yang L, et al. Protective Role of Liriodendrin in Sepsis-Induced Acute Lung Injury. Inflammation. 2016 Oct;39(5):1805-13.
- [5]. Zhang Z, et al. Protective role of liriodendrin in mice with dextran sulphate sodium-induced ulcerative colitis. International immunopharmacology. 2017 Nov;52:203-210.
- [6]. Qiu Y, et al. Liriodendrin stimulates proliferation and milk protein synthesis of mammary epithelial cells via the PI3K-DDX18 signaling. In vitro cellular & developmental biology. Animal. 2024 Sep;60(8):949-958.
