1. Metabolic Enzyme/Protease
    Immunology/Inflammation
    NF-κB
    Apoptosis
  2. Angiotensin-converting Enzyme (ACE)
    Toll-like Receptor (TLR)
    NF-κB
    TNF Receptor
    Interleukin Related
  3. Fosfenopril

Fosfenopril (Synonyms: Fosinoprilat; Fosinoprilic acid; SQ 27519)

Cat. No.: HY-107352
Handling Instructions

Fosfenopril (Fosinoprilat) is a potent angiotensin converting enzyme (ACE) inhibitor. Fosfenopril alleviates lipopolysaccharide (LPS)-induced inflammation by inhibiting TLR4/NF-κB signaling in monocytes.

For research use only. We do not sell to patients.

Fosfenopril Chemical Structure

Fosfenopril Chemical Structure

CAS No. : 95399-71-6

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Description

Fosfenopril (Fosinoprilat) is a potent angiotensin converting enzyme (ACE) inhibitor. Fosfenopril alleviates lipopolysaccharide (LPS)-induced inflammation by inhibiting TLR4/NF-κB signaling in monocytes[1][2].

IC50 & Target

TLR4

 

NF-κB

 

IL-6

 

IL-1β

 

In Vitro

Fosfenopril (0-10 μM, 5 min) inhibits the expression of TLR4 which is elevated by LPS[1].
Fosfenopril (0-10 μM, 1 h)attenuates the expression of NF-κB which is activated by LPS[1].
Fosfenopril inhibits LPS-induced cytokines (IL-6, IL-1β, and TNF-α) expression[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: THP1 cells
Concentration: 0, 0.25, 0.5, 1, 5, and 10 μM
Incubation Time: 1 h
Result: Down-regulated the expression of NF-κB protein.

RT-PCR[1]

Cell Line: THP1 cells
Concentration: 0, 0.25, 0.5, 1, 5, and 10 μM
Incubation Time: 5 min
Result: Showed a dose-dependent inhibitory effect on the TLR4 expression.
In Vivo

Fosfenopril (0.5 mg/kg bolus plus 0.1 mg/kg/min, IV, once) increases p-aminohippurate (PAH) clearance and glomerular filtration rate (GFR) in dogs[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Famale mongrel dogs (n=7)[3]
Dosage: 0.5 mg/kg (1.1 mumol/kg) bolus plus 0.1 mg/kg/min (0.22 mumol/kg/min)
Administration: IV, once
Result: Increased p-aminohippurate (PAH) clearance and glomerular filtration rate (GFR) by 25 and 16%, respectively without changing arterial pressure (AP).
Molecular Weight

435.49

Formula

C23H34NO5P

CAS No.
SMILES

O=P(CCCCC1=CC=CC=C1)(O)CC(N2C[[email protected]](C3CCCCC3)C[[email protected]]2C(O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Fosfenopril
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HY-107352
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