Tex14 - testis expressed gene 14 Gene

Species: Mus musculus

Gene Type: protein coding

Gene ID: 83560

Summary

Predicted to enable protein kinase binding activity. Involved in several processes, including intercellular bridge organization; mitotic spindle assembly checkpoint signaling; and nuclear division. Acts upstream of or within cellular response to leukemia inhibitory factor; negative regulation of cytokinesis; and negative regulation of protein binding activity. Located in intercellular bridge; kinetochore; and midbody. Is expressed in germ cell of ovary; germ cell of testis; ovary; and primordial germ cell of gonad. Human ortholog(s) of this gene implicated in spermatogenic failure 23. Orthologous to human TEX14 (testis expressed 14, intercellular bridge forming factor). [provided by Alliance of Genome Resources, Apr 2022]

Tex14 Products (2)

mRNA	Protein	Name
NM_001199293.1	NP_001186222.1	inactive serine/threonine-protein kinase TEX14 isoform a
NM_031386.2	NP_113563.2	inactive serine/threonine-protein kinase TEX14 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20176808	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in attachment of spindle microtubules to kinetochore	IMP IMP: Inferred from mutant phenotype	22405274	MGI
acts upstream of or within cellular response to leukemia inhibitory factor	IEP IEP: Inferred from expression pattern	20439489	MGI
involved in intercellular bridge organization	IDA IDA: Inferred from direct assay	16549803	MGI
involved in male meiotic nuclear division	IMP IMP: Inferred from mutant phenotype	16549803	MGI
involved in mitotic sister chromatid separation	IMP IMP: Inferred from mutant phenotype	22405274	MGI
involved in mitotic spindle assembly checkpoint signaling	IMP IMP: Inferred from mutant phenotype	22405274	MGI
acts upstream of or within negative regulation of cytokinesis	IDA IDA: Inferred from direct assay	20176808	MGI
acts upstream of or within negative regulation of protein binding	IDA IDA: Inferred from direct assay	20176808	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in intercellular bridge	IDA IDA: Inferred from direct assay	16549803	MGI
located in kinetochore	IDA IDA: Inferred from direct assay	22405274	MGI
located in midbody	IDA IDA: Inferred from direct assay	22405274	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
inactive serine/threonine-protein kinase TEX14	testis-expressed protein 14 testis-expressed sequence 14 protein

Tex14 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Tex14	Q7M6U3	Cep55	Mus musculus	Q8BT07	Anti Tag CoIP	20176808
Intra	Tex14	Q7M6U3	Cep55	Mus musculus	Q8BT07	IF	20176808
Intra	Tex14	Q7M6U3	Cep55	Mus musculus	Q8BT07	Y2H	20176808

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14391	TEX14 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tex14	NCBI	NCBI:56155