TEX14 - testis expressed 14, intercellular bridge forming factor Gene

Also Known as CT113; SPGF23

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 56155

About TEX14

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:58,556,678-58,692,045 (from NCBI)

This gene has 6 transcripts (splice variants), 129 orthologues and is associated with 2 phenotypes. Restricted expression toward testis (RPKM 18.9).

Summary

The protein encoded by this gene is necessary for intercellular bridges in germ cells, which are required for spermatogenesis. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011]

TEX14 Products (3)

mRNA Protein Name
NM_001201457.2 NP_001188386.1 inactive serine/threonine-protein kinase TEX14 isoform c
NM_031272.5 NP_112562.3 inactive serine/threonine-protein kinase TEX14 isoform b
NM_198393.4 NP_938207.2 inactive serine/threonine-protein kinase TEX14 isoform a

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20176808 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
22405274 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TEX14 Protein Structure

Ank_2

Ank_2: Ankyrin repeats (3 copies) (27 - 118)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (289 - 500)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1497 a.a.
Protein Preferred Names Protein Names

inactive serine/threonine-protein kinase TEX14

  • cancer/testis antigen 113

TEX14 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TEX14 Q8IWB6 LHX3 Homo sapiens Q9UBR4-2
Y2H Prey Pooling
32296183
Intra
TEX14 Q8IWB6 LHX3 Homo sapiens Q9UBR4-2
Y2H Array
32296183
Intra
TEX14 Q8IWB6 LHX3 Homo sapiens Q9UBR4-2
Validated Y2H
32296183
Intra
TEX14 Q8IWB6 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
TEX14 Q8IWB6 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
TEX14 Q8IWB6 LMO4 Homo sapiens P61968
Y2H Prey Pooling
32296183
Intra
TEX14 Q8IWB6 LMO4 Homo sapiens P61968
Y2H Array
32296183
Intra
TEX14 Q8IWB6 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Intra
TEX14 Q8IWB6 DDIT4L Homo sapiens Q96D03
Validated Y2H
32296183
Intra
TEX14 Q8IWB6 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
Intra
TEX14 Q8IWB6 CEP55 Homo sapiens Q53EZ4
Pull Down
32707033
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Spermatogenic Failure 23

  • SPGF23
Male Infertility With Azoospermia Or Oligozoospermia Due To Single Gene Mutation
Spermatogenic Failure

  • Azoospermia

  • Spgf

  • Spermatogenic Failure, Susceptibility To

  • Absent Sperm

  • Aspermatogenesis

  • Infertility Due To Azoospermia

  • Hypospermatogenesis

  • Azoospermatism
Spermatogenic Failure 5

  • Male Infertility With Large-Headed, Multiflagellar, Polyploid Spermatozoa

  • Infertility Associated With Multi-Tailed Spermatozoa And Excessive Dna

  • SPGF5

  • Macrocephalic Sperm Head Syndrome

  • Male Infertility Due To Macrozoospermia

  • Infertility Associated With Multitailed Spermatozoa And Excessive Dna

  • Macrozoospermia

  • Male Infertility Due To Large-Headed Multiflagellar Polyploid Spermatozoa

  • Infertility Associated With Multi-Tailed Spermatozoa And Excessive Deoxyribonucleic Acid

  • Large-Headed Multiflagellar Polyploid Spermatozoa

  • Male Infertility With Large-Headed Multiflagellar Polyploid Spermatozoa
Spermatogenic Failure, X-Linked, 1

  • Sertoli Cell-Only Syndrome

  • Germinal Cell Aplasia

  • Del Castillo Syndrome

  • SPGFX1

  • X-Linked Spermatogenic Failure 1

  • Congenital Absence Of Germinal Epithelium Of Testes
Orchitis

  • Inflammation Of Testis

  • Orchititis

  • Mumps Orchitis
Hemochromatosis, Type 1

  • Hemochromatosis

  • Hemochromatosis Type 1

  • Hereditary Hemochromatosis

  • Hh

  • HFE1

  • Hfe Hemochromatosis, Modifier Of

  • Symptomatic Form Of Classic Hemochromatosis

  • Symptomatic Form Of Hemochromatosis Type 1

  • Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis

  • Haemochromatosis

  • Iron Storage Disorder

  • Bronze Diabetes

  • Hereditary Haemochromatosis

  • Hlah

  • Hfe

  • Hemochromatosis, Hereditary

  • Diabetes Bronze

  • Classic Hemochromatosis

  • Hfe-Associated Hereditary Hemochromatosis

  • Hemochromatosis Classic

  • Bronzed Cirrhosis

  • Familial Hemochromatosis

  • Genetic Hemochromatosis

  • Hc

  • Pigmentary Cirrhosis

  • Primary Hemochromatosis

  • Troisier-Hanot-Chauffard Syndrome

  • Von Recklenhausen-Applebaum Disease

  • Hemochromatosis 1

  • Primary Hereditary Hemochromatosis

  • Bronze Cirrhosis
Vas Deferens, Congenital Bilateral Aplasia Of

  • Congenital Bilateral Absence Of Vas Deferens

  • CBAVD

  • Cavd

  • Congenital Bilateral Aplasia Of Vas Deferens

  • Congenital Bilateral Absence Of The Vas Deferens

  • Congenital Bilateral Agenesis Of Vas Deferens

  • Absence Of Vas Deferens

  • Absent Vasa

  • Congenital Absence Of Vas Deferens

  • Congenital Aplasia Of Vas Deferens

  • Absent Vas Deferens

  • Vas Deferens, Congenital Bilateral Absence
Cryptorchidism, Unilateral Or Bilateral

  • Cryptorchidism

  • Undescended Testicle

  • Undescended Testis

  • Cryptorchism

  • Undescended Testicles

  • CRYPTO

  • Impaired Testicular Descent

  • Cryptosporidiosis

  • Retained Testis

  • Unilateral Cryptorchidism

  • Unilateral Undescended Testis

  • Nondescent Unilateral Testicle

  • Unilateral Cryptorchism

  • Ectopic Testis, Unilateral

  • Bilateral Cryptorchidism

  • Bilateral Cryptorchism

  • Bilateral Nondescent Testicle

  • Bilateral Undescended Testes

  • Bilateral Ectopic Testes
Galloway-Mowat Syndrome

  • Galloway Mowat Syndrome

  • Galloway Syndrome

  • Hiatal Hernia-Microcephaly-Nephrosis, Galloway Type

  • Microcephaly Nephrosis Syndrome

  • Microcephaly, Hiatal Hernia, And Nephrotic Syndrome

  • Nephrosis Neuronal Dysmigration Syndrome

  • Microcephaly-Hiatus Hernia-Nephrotic Syndrome

  • Nephrosis-Neuronal Dysmigration Syndrome
Fanconi Anemia, Complementation Group A

  • Fanconi Anemia

  • Fanconi Pancytopenia

  • Fanconi Anemia Complementation Group A

  • FANCA

  • Fa

  • Fanconi Panmyelopathy

  • Fanconi'S Anemia

  • Fanconi Anaemia

  • Fanconi'S Anaemia

  • Fanconi Hypoplastic Anemia

  • Estren-Dameshek Variant Of Fanconi Anemia

  • Estren-Dameshek Variant Of Fanconi Pancytopenia

  • Fanconi Anemia Estren-Dameshek Variant

  • Fanconis Anemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14391 TEX14 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TEX14 VGNC VGNC:97659
Rattus norvegicus TEX14 RGD RGD:1305437
Mus musculus TEX14 MGD MGI:1933227
Bos taurus TEX14 VGNC VGNC:35762
Macaca mulatta TEX14 VGNC VGNC:99297
Canis familiaris TEX14 VGNC VGNC:47267
Others TEX14 NCBI