JAM3 - junctional adhesion molecule 3 Gene

Homo sapiens

Also known as JAMC; JAM-2; JAM-3; JAM-C

Gene ID: 83700 | Gene type: protein coding

About JAM3

Cytogenetic location: 11q25 Genomic coordinates (GRCh38): 11:134,069,072-134,152,001 (from NCBI)

This gene has 8 transcripts (splice variants), 276 orthologues, 14 paralogues and is associated with 3 phenotypes. Broad expression in placenta (RPKM 57.0), testis (RPKM 33.0) and 22 other tissues.

Summary

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. Unlike other proteins in this family, the this protein is unable to adhere to leukocyte cell lines and only forms weak homotypic interactions. The encoded protein is a member of the junctional adhesion molecule protein family and acts as a receptor for another member of this family. A mutation in an intron of this gene is associated with hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]

JAM3 Products(2)

mRNA	Protein	Name
NM_001205329.2	NP_001192258.1	junctional adhesion molecule C isoform 2 precursor
NM_032801.5	NP_116190.3	junctional adhesion molecule C isoform 1 precursor

JAM3 Protein Structure

V-set

Ig_2

0
100
200
310 a.a.

Protein Preferred Names

Protein Names

junctional adhesion molecule C

Recombinant JAM3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73850	JAM-C/CD323 Protein, Human (HEK293, Fc)	Q9BX67 (M1-N241)	≥95%
HY-P73851	JAM-C/CD323 Protein, Human (HEK293)	Q9BX67 (V32-N241)	≥95%

Related Diseases

Diseases

Alias

Hemorrhagic Destruction Of The Brain, Subependymal Calcification, And Cataracts

Porencephaly-Microcephaly-Bilateral Congenital Cataract Syndrome	HDBSCC
Hemorrhagic Destruction Of The Brain With Subependymal Calcification And Cataracts	Hemorrhagic Destruction Of The Brain, Subependymal Calcification, Cataracts

Jacobsen Syndrome

Chromosome 11q Deletion Syndrome	Partial 11q Monosomy Syndrome
Jacobsen Distal 11q Deletion Syndrome	JBS
11q Partial Monosomy Syndrome	Chromosome 11q Deletion
11q Deletion	11q Monosomy
Deletion 11q	Monosomy 11q
Partial Monosomy 11q	11q Deletion Disorder
11q Deletion Syndrome	11q Terminal Deletion Disorder
11q- Deletion Syndrome	11q23 Deletion Disorder
Jacobsen Thrombocytopenia	11q Terminal Deletion Syndrome
Del(11)(Q23.3)	Del(11)(Qter)
Distal Deletion 11q	Distal Monosomy 11q
Monosomy 11qter	Telomeric Deletion 11q
Paris-Trousseau Thrombocytopenia

Pseudo-Torch Syndrome 1

Pseudo-Torch Syndrome	Band-Like Calcification With Simplified Gyration And Polymicrogyria
Blcpmg	PTORCH1
Baraitser-Brett-Piesowicz Syndrome	Baraitser-Reardon Syndrome
Bilateral Band-Like Calcification With Polymicrogyria	Blc-Pmg
Microcephaly-Intracranial Calcification-Intellectual Disability Syndrome	Congenital Intrauterine Infection-Like Syndrome
Baraitser Brett Piesowicz Syndrome	Microcephaly - Intracranial Calcification - Intellectual Disability

Psoriatic Arthritis

Psoriatic Arthritis, Susceptibility To	Psoriatic Arthropathy
Arthropathic Psoriasis	Arthritis, Psoriatic
Arthritis Psoriatica	PSORAS
Arthritic Psoriasis	Psoriasis Arthropathica
Arthritis Psoriatic	Arthritis, Psoriatic, Susceptibility To

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07028	JAM3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	JAM3	RGD	RGD:1303248
Mus musculus	JAM3	MGD	MGI:1933825
Macaca mulatta	JAM3	VGNC	VGNC:73836
Canis familiaris	JAM3	VGNC	VGNC:53419
Bos taurus	JAM3	VGNC	VGNC:50018
Felis catus	JAM3	VGNC	VGNC:63002
Others	JAM3	NCBI