JAM3 - junctional adhesion molecule 3 Gene

Also Known as JAMC; JAM-2; JAM-3; JAM-C

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 83700

About JAM3

Cytogenetic location: 11q25 Genomic coordinates (GRCh38): 11:134,069,072-134,152,001 (from NCBI)

This gene has 8 transcripts (splice variants), 276 orthologues, 14 paralogues and is associated with 3 phenotypes. Broad expression in placenta (RPKM 57.0), testis (RPKM 33.0) and 22 other tissues.

Summary

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. Unlike Other proteins in this family, the this protein is unable to adhere to leukocyte cell lines and only forms weak homotypic interactions. The encoded protein is a member of the junctional adhesion molecule protein family and acts as a receptor for another member of this family. A mutation in an intron of this gene is associated with hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]

JAM3 Products (2)

mRNA Protein Name
NM_001205329.2 NP_001192258.1 junctional adhesion molecule C isoform 2 precursor
NM_032801.5 NP_116190.3 junctional adhesion molecule C isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cell-cell adhesion mediator activity IDA
IDA: Inferred from direct assay
11823489 GOA
enables integrin binding IPI
IPI: Inferred from physical interaction
12208882 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11590146 GOA
Biological Process GO Annotation Evidence References Source
involved in adherens junction assembly IMP
IMP: Inferred from mutant phenotype
19060272 GOA
involved in angiogenesis IDA
IDA: Inferred from direct assay
20592283 GOA
involved in apical protein localization IMP
IMP: Inferred from mutant phenotype
19060272 GOA
involved in cell-cell adhesion IDA
IDA: Inferred from direct assay
11823489 GOA
involved in cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
24357068 GOA
involved in granulocyte migration IMP
IMP: Inferred from mutant phenotype
19060272 GOA
involved in hematopoietic stem cell migration to bone marrow IMP
IMP: Inferred from mutant phenotype
24357068 GOA
involved in heterotypic cell-cell adhesion IDA
IDA: Inferred from direct assay
12208882 GOA
involved in negative regulation of cell adhesion mediated by integrin IMP
IMP: Inferred from mutant phenotype
19461049 GOA
involved in negative regulation of integrin activation IMP
IMP: Inferred from mutant phenotype
19461049 GOA
acts upstream of or within positive regulation of membrane permeability IMP
IMP: Inferred from mutant phenotype
31926946 GOA
acts upstream of or within positive regulation of monocyte extravasation IMP
IMP: Inferred from mutant phenotype
31926946 GOA
involved in protein localization to cell junction IMP
IMP: Inferred from mutant phenotype
19060272 GOA
involved in protein localization to cell surface IMP
IMP: Inferred from mutant phenotype
19060272 GOA
involved in regulation of neutrophil chemotaxis IDA
IDA: Inferred from direct assay
15194813 GOA
Cellular Component GO Annotation Evidence References Source
colocalizes with bicellular tight junction IDA
IDA: Inferred from direct assay
28196865 GOA
located in cell-cell contact zone IDA
IDA: Inferred from direct assay
15994945 GOA
located in cell-cell junction IMP
IMP: Inferred from mutant phenotype
19461049 GOA
located in desmosome IDA
IDA: Inferred from direct assay
15194813 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
20592283 GOA
part of filamentous actin IDA
IDA: Inferred from direct assay
19060272 GOA
located in microvillus IDA
IDA: Inferred from direct assay
19060272 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
11590146 GOA
part of protein complex involved in cell adhesion IDA
IDA: Inferred from direct assay
11590146 GOA
located in tight junction IDA
IDA: Inferred from direct assay
19060272 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

JAM3 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (35 - 129)

Ig_2

Ig_2: Immunoglobulin domain (144 - 228)

  • 0
  • 100
  • 200
  • 310 a.a.
Protein Preferred Names Protein Names

junctional adhesion molecule C

JAM3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
JAM3 Q9BX67 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
JAM3 Q9BX67 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
JAM3 Q9BX67 JAM2 Homo sapiens P57087
Protein Array
21982860
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant JAM3 Proteins

Cat. No. Product Name Accession Purity
HY-P73850 JAM-C/CD323 Protein, Human (HEK293, Fc) Q9BX67 (V32-N241) ≥ 85%, as determined by reducing SDS-PAGE.
HY-P73851 JAM-C/CD323 Protein, Human (HEK293) Q9BX67 (V32-N241) ≥ 95%, as determined by reducing SDS-PAGE.

JAM3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P84767 JAM3 Antibody (YA4464) WB, FC, ELISA Human
HY-P84767A JAM3 Antibody (YA4464)(PBS only) WB, FC, ELISA Human

Related Diseases

Diseases Alias
Hemorrhagic Destruction Of The Brain, Subependymal Calcification, And Cataracts

  • Porencephaly-Microcephaly-Bilateral Congenital Cataract Syndrome

  • HDBSCC

  • Hemorrhagic Destruction Of The Brain With Subependymal Calcification And Cataracts

  • Hemorrhagic Destruction Of The Brain, Subependymal Calcification, Cataracts
Jacobsen Syndrome

  • Chromosome 11q Deletion Syndrome

  • Partial 11q Monosomy Syndrome

  • Jacobsen Distal 11q Deletion Syndrome

  • JBS

  • 11q Partial Monosomy Syndrome

  • Chromosome 11q Deletion

  • 11q Deletion

  • 11q Monosomy

  • Deletion 11q

  • Monosomy 11q

  • Partial Monosomy 11q

  • 11q Deletion Disorder

  • 11q Deletion Syndrome

  • 11q Terminal Deletion Disorder

  • 11q- Deletion Syndrome

  • 11q23 Deletion Disorder

  • Jacobsen Thrombocytopenia

  • 11q Terminal Deletion Syndrome

  • Del(11)(Q23.3)

  • Del(11)(Qter)

  • Distal Deletion 11q

  • Distal Monosomy 11q

  • Monosomy 11qter

  • Telomeric Deletion 11q

  • Paris-Trousseau Thrombocytopenia
Pseudo-Torch Syndrome 1

  • Pseudo-Torch Syndrome

  • Band-Like Calcification With Simplified Gyration And Polymicrogyria

  • Blcpmg

  • PTORCH1

  • Baraitser-Brett-Piesowicz Syndrome

  • Baraitser-Reardon Syndrome

  • Bilateral Band-Like Calcification With Polymicrogyria

  • Blc-Pmg

  • Microcephaly-Intracranial Calcification-Intellectual Disability Syndrome

  • Congenital Intrauterine Infection-Like Syndrome

  • Baraitser Brett Piesowicz Syndrome

  • Microcephaly - Intracranial Calcification - Intellectual Disability
Psoriatic Arthritis

  • Psoriatic Arthritis, Susceptibility To

  • Psoriatic Arthropathy

  • Arthropathic Psoriasis

  • Arthritis, Psoriatic

  • Arthritis Psoriatica

  • PSORAS

  • Arthritic Psoriasis

  • Psoriasis Arthropathica

  • Arthritis Psoriatic

  • Arthritis, Psoriatic, Susceptibility To
Rheumatoid Arthritis

  • RA

  • Arthritis, Rheumatoid

  • Rheumatoid Arthritis, Susceptibility To

  • Arthritis Or Polyarthritis, Rheumatic

  • Atrophic Arthritis

  • Rheumatism Arthritis

  • Rheumatoid Polyarthritis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07028 JAM3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19344 Jam3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25835 Jam3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus JAM3 RGD RGD:1303248
Mus musculus JAM3 MGD MGI:1933825
Macaca mulatta JAM3 VGNC VGNC:73836
Canis familiaris JAM3 VGNC VGNC:53419
Bos taurus JAM3 VGNC VGNC:50018
Felis catus JAM3 VGNC VGNC:63002
Others JAM3 NCBI