ADTRP - androgen dependent TFPI regulating protein Gene

Also Known as AIG1L; C6orf105; dJ413H6.1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84830

About ADTRP

Cytogenetic location: 6p24.1 Genomic coordinates (GRCh38): 6:11,713,523-11,778,803 (from NCBI)

This gene has 10 transcripts (splice variants), 199 orthologues and 1 paralogue. Biased expression in small intestine (RPKM 12.0), duodenum (RPKM 8.7) and 8 other tissues.

Summary

Enables hydrolase activity. Involved in several processes, including cell migration involved in sprouting angiogenesis; negative regulation of secretion by cell; and positive regulation of macromolecule metabolic process. Located in caveola and cell surface. [provided by Alliance of Genome Resources, Apr 2022]

ADTRP Products (2)

mRNA	Protein	Name
NM_001143948.2	NP_001137420.1	androgen-dependent TFPI-regulating protein isoform 1
NM_032744.4	NP_116133.1	androgen-dependent TFPI-regulating protein isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables hydrolase activity	IMP IMP: Inferred from mutant phenotype	27018888	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell migration involved in sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	28341552	GOA
involved in cellular response to oxidised low-density lipoprotein particle stimulus	IMP IMP: Inferred from mutant phenotype	28341552	GOA
involved in cellular response to steroid hormone stimulus	IEP IEP: Inferred from expression pattern	21868574	GOA
involved in long-chain fatty acid catabolic process	IMP IMP: Inferred from mutant phenotype	27018888	GOA
involved in negative regulation of blood coagulation	IMP IMP: Inferred from mutant phenotype	21868574	GOA
involved in negative regulation of extracellular matrix constituent secretion	IMP IMP: Inferred from mutant phenotype	28341552	GOA
involved in negative regulation of leukocyte cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	28341552	GOA
involved in negative regulation of leukocyte migration	IMP IMP: Inferred from mutant phenotype	28341552	GOA
involved in negative regulation of lymphocyte migration	IMP IMP: Inferred from mutant phenotype	28341552	GOA
involved in negative regulation of protein secretion	IMP IMP: Inferred from mutant phenotype	28341552	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	21868574	GOA
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	28341552	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in caveola	IDA IDA: Inferred from direct assay	21868574	GOA
located in cell surface	IDA IDA: Inferred from direct assay	21868574	GOA
located in membrane	IDA IDA: Inferred from direct assay	27018888	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADTRP Protein Structure

Far-17a_AIG1

0
100
200
230 a.a.

Protein Preferred Names	Protein Names
androgen-dependent TFPI-regulating protein	FAHFA hydrolase ADTRP

Related Diseases

Diseases	Alias
Nonobstructive Coronary Artery Disease	Non-Cad Non-Obstructive Coronary Artery Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P11655	NOTA-TATE	Ligand	/	Unkown
HY-P11806	DLeu-DTyr-Gly-DTrp-Gly-DTyr-DTrp		/	Unkown
HY-P11807	DArg-DLys-DTyr-DTyr-Gly-DTrp		/	Unkown
HY-RS00421	ADTRP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ADTRP	VGNC	VGNC:37680
Felis catus	ADTRP	VGNC	VGNC:102376
Mus musculus	ADTRP	MGD	MGI:1924596
Rattus norvegicus	ADTRP	RGD	RGD:1305679
Macaca mulatta	ADTRP	VGNC	VGNC:69661
Bos taurus	ADTRP	VGNC	VGNC:25702
Others	ADTRP	NCBI