RERG - RAS like estrogen regulated growth inhibitor Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 85004

About RERG

Cytogenetic location: 12p12.3 Genomic coordinates (GRCh38): 12:15,107,783-15,221,417 (from NCBI)

This gene has 9 transcripts (splice variants), 203 orthologues and 35 paralogues. Broad expression in endometrium (RPKM 41.3), adrenal (RPKM 21.0) and 16 other tissues.

Summary

RERG, a member of the Ras superfamily of GTPases, inhibits cell proliferation and tumor formation (Finlin et al., 2001 [PubMed 11533059]).[supplied by OMIM, Mar 2009]

RERG Products (2)

mRNA Protein Name
NM_001190726.2 NP_001177655.1 ras-related and estrogen-regulated growth inhibitor isoform 2
NM_032918.3 NP_116307.1 ras-related and estrogen-regulated growth inhibitor isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTPase activity IDA
IDA: Inferred from direct assay
11533059 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of cell growth IDA
IDA: Inferred from direct assay
11533059 GOA
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
11533059 GOA
involved in response to hormone IDA
IDA: Inferred from direct assay
11533059 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
11533059 GOA
located in nucleus IDA
IDA: Inferred from direct assay
11533059 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RERG Protein Structure

Ras

Ras: Ras family (8 - 168)

  • 0
  • 100
  • 199 a.a.
Protein Preferred Names Protein Names

ras-related and estrogen-regulated growth inhibitor

RERG Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RERG Q96A58 ARHGEF17 Homo sapiens Q96PE2
Anti Tag CoIP
33961781
Intra
RERG Q96A58 ARHGEF17 Homo sapiens Q96PE2
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11849 RERG Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RERG MGD MGI:2665139
Rattus norvegicus RERG RGD RGD:1562829
Canis familiaris RERG VGNC VGNC:45478
Macaca mulatta RERG VGNC VGNC:76740
Bos taurus RERG VGNC VGNC:33873
Felis catus RERG VGNC VGNC:64574
Others RERG NCBI