ARHGEF17 - Rho guanine nucleotide exchange factor 17 Gene

Also Known as TEM4; RHOGEF17; P164RHOGEF; p164-RhoGEF

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9828

About ARHGEF17

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:73,308,276-73,369,388 (from NCBI)

This gene has 7 transcripts (splice variants), 208 orthologues and 2 paralogues. Ubiquitous expression in endometrium (RPKM 12.7), fat (RPKM 10.8) and 24 other tissues.

Summary

Enables guanyl-nucleotide exchange factor activity. Acts upstream of or within actin Cytoskeleton organization. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

ARHGEF17 Products (1)

mRNA Protein Name
NM_014786.4 NP_055601.2 rho guanine nucleotide exchange factor 17

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
12071859 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within actin cytoskeleton organization IDA
IDA: Inferred from direct assay
12071859 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARHGEF17 Protein Structure

RhoGEF

RhoGEF: RhoGEF domain (1072 - 1253)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2063 a.a.
Protein Preferred Names Protein Names

rho guanine nucleotide exchange factor 17

  • 164 kDa Rho-specific guanine-nucleotide exchange factor

ARHGEF17 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ARHGEF17 Q96PE2 OTX1 Homo sapiens P32242
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Moyamoya Disease 1

  • Moyamoya Disease

  • Spontaneous Occlusion Of The Circle Of Willis

  • Mymy

  • Progressive Intracranial Arterial Occlusion

  • Moyamoya Syndrome

  • MYMY1

  • Cerebrovascular Moyamoya Disease

  • Moya-Moya Disease

  • Progressive Intracranial Occlusive Arteropathy

  • Idiopathic Moyamoya Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00952 ARHGEF17 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ARHGEF17 VGNC VGNC:59902
Mus musculus ARHGEF17 MGD MGI:2673002
Rattus norvegicus ARHGEF17 RGD RGD:1309890
Bos taurus ARHGEF17 VGNC VGNC:26109
Canis familiaris ARHGEF17 VGNC VGNC:38078
Macaca mulatta ARHGEF17 VGNC VGNC:69880
Others ARHGEF17 NCBI