DNAJC14 - DnaJ heat shock protein family (Hsp40) member C14 Gene

Also Known as DNAJ; HDJ3; LIP6; DRIP78

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 85406

About DNAJC14

Cytogenetic location: 12q13.2 Genomic coordinates (GRCh38): 12:55,820,985-55,830,775 (from NCBI)

This gene has 5 transcripts (splice variants), 226 orthologues and 20 paralogues. Ubiquitous expression in testis (RPKM 16.8), thyroid (RPKM 12.6) and 25 other tissues.

Summary

Predicted to be involved in protein transport. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]

DNAJC14 Products (5)

mRNA Protein Name
NM_001394687.1 NP_001381616.1 dnaJ homolog subfamily C member 14 isoform 1
NM_001394688.1 NP_001381617.1 dnaJ homolog subfamily C member 14 isoform 1
NM_001394689.1 NP_001381618.1 dnaJ homolog subfamily C member 14 isoform 1
NM_001394690.1 NP_001381619.1 dnaJ homolog subfamily C member 14 isoform 2
NM_032364.6 NP_115740.5 dnaJ homolog subfamily C member 14 isoform 1
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DNAJC14 Protein Structure

DnaJ

DnaJ: DnaJ domain (443 - 504)

Jiv90

Jiv90: Cleavage inducing molecular chaperone (530 - 621)

  • 0
  • 200
  • 400
  • 600
  • 702 a.a.
Protein Preferred Names Protein Names

dnaJ homolog subfamily C member 14

  • DnaJ (Hsp40) homolog, subfamily C, member 14

DNAJC14 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DNAJC14 Q6Y2X3 SARNP Homo sapiens P82979 33961781
Intra
DNAJC14 Q6Y2X3 SARNP Homo sapiens P82979 28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Yellow Fever
  • Urban Yellow Fever

  • Jungle Yellow Fever

  • Sylvatic Yellow Fever

  • Yf

  • Yellow Fever, Sylvan

  • Bronze John

  • Yellow Jack

  • Yf- [Yellow Fever]

  • Febris Flava

Deafness, Autosomal Recessive 4, With Enlarged Vestibular Aqueduct
  • Enlarged Vestibular Aqueduct

  • DFNB4

  • Neurosensory Nonsyndromic Recessive Deafness 4

  • Enlarged Vestibular Aqueduct Syndrome

  • Nsrd4

  • Autosomal Recessive Nonsyndromic Deafness 4

  • Dilated Vestibular Aqueduct

  • Dva

  • Enlarged Vestibular Aqueduct, Digenic

  • Autosomal Recessive Deafness 4 With Enlarged Vestibular Aqueduct

  • Large Vestibular Aqueduct Syndrome

  • Deafness, Autosomal Recessive, 4

  • Deafness Neurosensory Autosomal Recessive 4

  • Eva

  • Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 4

  • Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 4

  • Deafness, Autosomal Recessive, Type 4 , With Enlarged Vestibular Aqueduct

Schizophrenia
  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1

Familial Glucocorticoid Deficiency
  • Glucocorticoid Deficiency

  • Acth Resistance

  • Adrenal Unresponsiveness To Acth

  • Hereditary Unresponsiveness To Adrenocorticotropic Hormone

  • Isolated Glucocorticoid Deficiency

  • Glucocorticoid Deficiency, Familial

  • Glucocorticoid Deficiency 1

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus DNAJC14 RGD RGD:620489
Canis familiaris DNAJC14 VGNC VGNC:108204
Mus musculus DNAJC14 MGD MGI:1921580
Others DNAJC14 NCBI