SARNP - SAP domain containing ribonucleoprotein Gene

Also Known as HCC1; THO1; CIP29; HSPC316

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84324

About SARNP

Cytogenetic location: 12q13.2 Genomic coordinates (GRCh38): 12:55,752,463-55,817,724 (from NCBI)

This gene has 6 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in testis (RPKM 27.2), endometrium (RPKM 26.0) and 25 other tissues.

Summary

This gene encodes a protein that is upregulated in response to various cytokines. The encoded protein may play a role in cell cycle progression. A translocation between this gene and the myeloid/lymphoid leukemia gene, resulting in expression of a chimeric protein, has been associated with acute myelomonocytic leukemia. Pseudogenes exist on chromosomes 7 and 8. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]

SARNP Products (1)

mRNA Protein Name
NM_033082.4 NP_149073.1 SAP domain-containing ribonucleoprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14667819 GOA
Biological Process GO Annotation Evidence References Source
involved in mRNA export from nucleus IDA
IDA: Inferred from direct assay
20844015 GOA
Cellular Component GO Annotation Evidence References Source
located in nuclear speck IDA
IDA: Inferred from direct assay
20844015 GOA
part of transcription export complex IDA
IDA: Inferred from direct assay
20844015 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SARNP Protein Structure

SAP

SAP: SAP domain (8 - 42)

  • 0
  • 100
  • 200
  • 210 a.a.
Protein Preferred Names Protein Names

SAP domain-containing ribonucleoprotein

  • cytokine induced protein 29 kDa

SARNP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SARNP P82979 DDX39A Homo sapiens O00148
Anti Tag CoIP
33961781
Intra
SARNP P82979 DDX39A Homo sapiens O00148
Y2H Array
25416956
Intra
SARNP P82979 DDX39A Homo sapiens O00148
Y2H Prey Pooling
25416956
Intra
SARNP P82979 DDX39B Homo sapiens Q13838
Y2H Prey Pooling
32296183
Intra
SARNP P82979 DDX39B Homo sapiens Q13838
Anti Tag CoIP
33961781
Intra
SARNP P82979 DDX39B Homo sapiens Q13838
Validated Y2H
32296183
Intra
SARNP P82979 DDX39B Homo sapiens Q13838
Y2H Array
32296183
Intra
SARNP P82979 U2AF1 Homo sapiens Q01081
FRET
18559666
Intra
SARNP P82979 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
SARNP P82979 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
SARNP P82979 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
SARNP P82979 U2AF2 Homo sapiens P26368
FRET
18559666
Intra
SARNP P82979 U2AF2 Homo sapiens P26368
Anti Bait CoIP
18559666
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Acute Myelomonocytic Leukemia

  • Acute Myeloid Leukemia With Abnormal Bone Marrow Eosinophils Inv(16)(P13q22) Or T(16

  • 16)(P13

  • Q22)

  • Aml M4

  • Ammol

  • Acute Myeloblastic Leukemia Type 4

  • Aml With Abnormal Bone Marrow Eosinophils Inv(16)(P13q22) Or T(16

  • 16)(P13

  • Q22)

  • Aml-M4

  • Aml With Inv(16)(P13.1q22) Or T(16

  • 16)(P13.1

  • Q22)

  • Cbfb-Myh11

  • Leukemia Myelomonocytic Acute

  • Leukemia, Myelomonocytic, Acute

  • Acute Myelomonocytic Leukaemia Without Mention Of Remission

  • Myelomonocytic Leukaemia Nos
Non-Gestational Choriocarcinoma

  • Choriocarcinoma, Non-Gestational
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 1

  • Eec Syndrome

  • Rudiger Syndrome 1

  • Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip-Palate Syndrome 1

  • EEC1

  • Eec Syndrome 1

  • Eec Syndrome-1

  • Walker-Clodius Syndrome

  • Ectrodactyly-Ectodermal Dysplasia-Cleft Lip/Palate Syndrome

  • Eec

  • Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip-Palate Syndrome

  • Ectrodactyly-Ectodermal Dysplasia-Clefting Syndrome

  • Ectrodactyly-Cleft Lip/Palate Syndrome

  • Ectrodactyly-Ectodermal Dysplasia-Cleft Lip/Cleft Palate

  • Ectrodactyly-Ectodermal Dysplasia-Clefting Syndrome

  • Ectrodactyly, Ectodermal Dysplasia, Clefting Syndrome

  • Ectrodactyly-Cleft Lip-Palate Syndrome

  • Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome
Superficial Urinary Bladder Cancer

  • Superficial Urinary Bladder Carcinoma

  • Carcinoma Of Urinary Bladder, Superficial
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12447 SARNP Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SARNP RGD RGD:1305692
Canis familiaris SARNP VGNC VGNC:54543
Mus musculus SARNP MGD MGI:1913368
Others SARNP NCBI