GGACT - gamma-glutamylamine cyclotransferase Gene

Also Known as A2LD1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 87769

About GGACT

Cytogenetic location: 13q32.3 Genomic coordinates (GRCh38): 13:100,530,180-100,588,789 (from NCBI)

This gene has 7 transcripts (splice variants) and 202 orthologues. Biased expression in kidney (RPKM 12.0), fat (RPKM 1.8) and 13 other tissues.

Summary

The protein encoded by this gene aids in the proteolytic degradation of crosslinked fibrin by breaking down isodipeptide L-gamma-glutamyl-L-epsilon-lysine, a byproduct of fibrin degradation. The reaction catalyzed by the encoded gamma-glutamylaminecyclotransferase produces 5-oxo-L-proline and a free alkylamine. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Aug 2010]

GGACT Products (2)

mRNA Protein Name
NM_001195087.2 NP_001182016.1 gamma-glutamylaminecyclotransferase
NM_033110.3 NP_149101.1 gamma-glutamylaminecyclotransferase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables gamma-glutamylaminecyclotransferase activity IDA
IDA: Inferred from direct assay
20110353 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular modified amino acid catabolic process IDA
IDA: Inferred from direct assay
20110353 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GGACT Protein Structure

GGACT

GGACT: Gamma-glutamyl cyclotransferase, AIG2-like (4 - 119)

  • 0
  • 100
  • 153 a.a.
Protein Preferred Names Protein Names

gamma-glutamylaminecyclotransferase

  • AIG2-like domain 1

GGACT Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GGACT Q9BVM4 PLAAT5 Homo sapiens Q96KN8-3
Validated Y2H
25416956
Intra
GGACT Q9BVM4 PLAAT5 Homo sapiens Q96KN8-3
Y2H Prey Pooling
32296183
Intra
GGACT Q9BVM4 PLAAT5 Homo sapiens Q96KN8-3
Y2H Array
32296183
Intra
GGACT Q9BVM4 LDB2 Homo sapiens O43679
Y2H Array
32296183
Intra
GGACT Q9BVM4 LDB2 Homo sapiens O43679
Y2H Prey Pooling
32296183
Intra
GGACT Q9BVM4 ZBED1 Homo sapiens O96006
Y2H Array
32296183
Intra
GGACT Q9BVM4 ZBED1 Homo sapiens O96006
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GGACT Proteins

Cat. No. Product Name Accession Purity
HY-P70902 GGACT Protein, Human (His) Q9BVM4 (M1-R153) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-150729 ODN 1982 Inhibitor / Unkown
HY-RS05396 GGACT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21581 Ggact Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28099 Ggact Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GGACT MGD MGI:2385008
Rattus norvegicus GGACT RGD RGD:1304748
Canis familiaris GGACT VGNC VGNC:41196
Bos taurus GGACT VGNC VGNC:29338
Felis catus GGACT VGNC VGNC:62535
Macaca mulatta GGACT VGNC VGNC:72781
Others GGACT NCBI